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Gene Review

SMG5  -  SMG5 nonsense mediated mRNA decay factor

Homo sapiens

Synonyms: EST1-like protein B, EST1B, KIAA1089, LPTS-RP1, LPTS-interacting protein, ...


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High impact information on SMG5

  • The 14-3-3 site of SMG7 is conserved in SMG5 and SMG6 [1].
  • Here we show that SMG5 and SMG7 colocalize in cytoplasmic mRNA decay bodies, while SMG6 forms separate cytoplasmic foci [2].
  • In contrast, SMG5 requires SMG7 to trigger mRNA decay and to localize to decay bodies [2].
  • Overexpression of hSMG-5 mutants that retain interaction with P-hUPF1 but which cannot induce its dephosphorylation impair NMD, suggesting that NMD requires P-hUPF1 dephosphorylation [3].
  • This interaction is regulated by protein kinase A-mediated HDAC8 phosphorylation and protects human EST1B (hEST1B) from ubiquitin-mediated degradation [4].
  • Stable knock-down of Smg5 in mouse embryonic stem cells results in differentiation defects [5].

Biological context of SMG5


  1. SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway. Fukuhara, N., Ebert, J., Unterholzner, L., Lindner, D., Izaurralde, E., Conti, E. Mol. Cell (2005) [Pubmed]
  2. SMG7 acts as a molecular link between mRNA surveillance and mRNA decay. Unterholzner, L., Izaurralde, E. Mol. Cell (2004) [Pubmed]
  3. Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. Ohnishi, T., Yamashita, A., Kashima, I., Schell, T., Anders, K.R., Grimson, A., Hachiya, T., Hentze, M.W., Anderson, P., Ohno, S. Mol. Cell (2003) [Pubmed]
  4. Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation. Lee, H., Sengupta, N., Villagra, A., Rezai-Zadeh, N., Seto, E. Mol. Cell. Biol. (2006) [Pubmed]
  5. Smg6/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay. Li, T., Shi, Y., Wang, P., Guachalla, L.M., Sun, B., Joerss, T., Chen, Y.S., Groth, M., Krueger, A., Platzer, M., Yang, Y.G., Rudolph, K.L., Wang, Z.Q. EMBO. J. (2015) [Pubmed]
  6. Functional conservation of the telomerase protein Est1p in humans. Snow, B.E., Erdmann, N., Cruickshank, J., Goldman, H., Gill, R.M., Robinson, M.O., Harrington, L. Curr. Biol. (2003) [Pubmed]
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