Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

SMG7 - SMG7 nonsense mediated mRNA decay factor

Homo sapiens

Synonyms: C1orf16, EST1-like protein C, EST1C, KIAA0250, Protein SMG7, ...

Ohnishi, T. et al., Fukuhara, N. et al., Unterholzner, L. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on SMG7

The 14-3-3 site of SMG7 is conserved in SMG5 and SMG6 [1].
SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway [1].
Residues that bind phosphoserine-containing peptides in 14-3-3 are conserved at the equivalent positions in SMG7 [1].
SMG5 and SMG7 form a complex with UPF1 and interact with each other via their N-terminal domains [2].

Biological context of SMG7

Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7 [3].
SMG7 acts as a molecular link between mRNA surveillance and mRNA decay [2].

Other interactions of SMG7

In contrast, SMG5 requires SMG7 to trigger mRNA decay and to localize to decay bodies [2].

References

SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway. Fukuhara, N., Ebert, J., Unterholzner, L., Lindner, D., Izaurralde, E., Conti, E. Mol. Cell (2005) [Pubmed]
SMG7 acts as a molecular link between mRNA surveillance and mRNA decay. Unterholzner, L., Izaurralde, E. Mol. Cell (2004) [Pubmed]
Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. Ohnishi, T., Yamashita, A., Kashima, I., Schell, T., Anders, K.R., Grimson, A., Hachiya, T., Hentze, M.W., Anderson, P., Ohno, S. Mol. Cell (2003) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

SMG7	Bos taurus
SMG7	Canis lupus familiaris
smg7	Danio rerio
SMG7	Gallus gallus
SMG7	Macaca mulatta
Smg7	Mus musculus
SMG7	Pan troglodytes
Smg7	Rattus norvegicus
smg7	Xenopus (Silurana) tropicalis

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.