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Gene Review

SMG7  -  SMG7 nonsense mediated mRNA decay factor

Homo sapiens

Synonyms: C1orf16, EST1-like protein C, EST1C, KIAA0250, Protein SMG7, ...
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High impact information on SMG7

  • The 14-3-3 site of SMG7 is conserved in SMG5 and SMG6 [1].
  • SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway [1].
  • Residues that bind phosphoserine-containing peptides in 14-3-3 are conserved at the equivalent positions in SMG7 [1].
  • SMG5 and SMG7 form a complex with UPF1 and interact with each other via their N-terminal domains [2].

Biological context of SMG7


Other interactions of SMG7


  1. SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway. Fukuhara, N., Ebert, J., Unterholzner, L., Lindner, D., Izaurralde, E., Conti, E. Mol. Cell (2005) [Pubmed]
  2. SMG7 acts as a molecular link between mRNA surveillance and mRNA decay. Unterholzner, L., Izaurralde, E. Mol. Cell (2004) [Pubmed]
  3. Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. Ohnishi, T., Yamashita, A., Kashima, I., Schell, T., Anders, K.R., Grimson, A., Hachiya, T., Hentze, M.W., Anderson, P., Ohno, S. Mol. Cell (2003) [Pubmed]
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