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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

MORC3  -  MORC family CW-type zinc finger 3

Homo sapiens

Synonyms: KIAA0136, MORC family CW-type zinc finger protein 3, NXP2, ZCW5, ZCWCC3, ...
 
 
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High impact information on MORC3

  • When tethered to a promoter by fusion to Gal4, NXP-2 repressed transcription, consistent with a role for NXP-2 in SUMO-mediated repression [1].
  • NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression [1].
  • This cDNA encoded a 939-amino acid protein designated nuclear matrix protein NXP-2 [2].
  • NXP-2 was released from the nuclear matrix when RNase A was included in the buffer for nuclear matrix preparation [2].
  • The central region (amino acids 500-591) was demonstrated to be required for RNA binding by Northwestern analysis, although NXP-2 lacked a known RNA binding motif [2].
 

Biological context of MORC3

 

Analytical, diagnostic and therapeutic context of MORC3

References

  1. NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression. Rosendorff, A., Sakakibara, S., Lu, S., Kieff, E., Xuan, Y., DiBacco, A., Shi, Y., Shi, Y., Gill, G. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  2. The newly identified human nuclear protein NXP-2 possesses three distinct domains, the nuclear matrix-binding, RNA-binding, and coiled-coil domains. Kimura, Y., Sakai, F., Nakano, O., Kisaki, O., Sugimoto, H., Sawamura, T., Sadano, H., Osumi, T. J. Biol. Chem. (2002) [Pubmed]
  3. Mapping of a novel SH3 domain protein and two proteins of unknown function to human chromosome 21. Katsanis, N., Beck, J.A., Fisher, E.M. Hum. Genet. (1997) [Pubmed]
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