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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Nuclear Matrix

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Disease relevance of Nuclear Matrix


High impact information on Nuclear Matrix

  • The results suggest a model in which PcG and TrxG proteins regulate insulator function by establishing higher order domains of chromatin organization required for the assembly of functional insulators at the nuclear matrix [6].
  • Second, we find that the specific sequences bound to the yeast nuclear scaffold are the putative origins of replication (ARS elements) and a chromosomal centromere, CENIII [7].
  • Vimentin is largely associated with the nuclear matrix, probably as a corona external of filaments [8].
  • Using nuclease digestion, one can progressively cleave DNA from the loops, thereby isolating residual DNA that is progressively closer to the nuclear matrix anchorage sites [9].
  • Association of polyoma T antigen and DNA with the nuclear matrix from lytically infected 3T6 cells [10].

Chemical compound and disease context of Nuclear Matrix


Biological context of Nuclear Matrix


Anatomical context of Nuclear Matrix


Associations of Nuclear Matrix with chemical compounds

  • The potential involvement of the nuclear matrix and one of its components, a receptor binding factor (RBF-1) for steroid receptors of these genes, is discussed [25].
  • The nuclear matrix antigen recognized by the monoclonal antibody (mAb) B1C8 is a novel serine (S) and arginine (R)-rich protein associated with splicing complexes and is named here SRm160 (SR-related matrix protein of 160 kD) [26].
  • Agonist (oestradiol; E2) or partial antagonist (4-hydroxytamoxifen) slows ER recovery (t1/2 approximately 5-6 s), whereas the pure antagonist (ICI 182,780) and, surprisingly, proteasome inhibitors each immobilize ER to the nuclear matrix [27].
  • Further extraction of the nuclear matrices of HeLa or MCF-7 cells with 2 M sodium chloride uncovered a network of core filaments [28].
  • Extraction of the permeabilized cells with DNase I and 0.2 M ammonium sulfate revealed a striking maintenance of these replication granules and their distinct intranuclear arrangements with the remaining nuclear matrix structures despite the removal of greater than 90% of the total nuclear DNA [29].

Gene context of Nuclear Matrix

  • XIST RNA remains with the nuclear matrix fraction after removal of chromosomal DNA [30].
  • Fractionation of nuclei from FGF-2-treated cells indicates that nuclear FGFR-1 is localized to the nuclear matrix, suggesting that the receptor may play a role in regulating gene activity [31].
  • Thus, RCC1 protein locates on the chromatin and is not a component of the nuclear matrix [32].
  • We show here that the transcriptionally active AML-1B binds to the nuclear matrix, and the inactive AML-1 does not [33].
  • Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBF-alpha transcription factors [33].

Analytical, diagnostic and therapeutic context of Nuclear Matrix


  1. Lamins A and C appear during retinoic acid-induced differentiation of mouse embryonal carcinoma cells. Lebel, S., Lampron, C., Royal, A., Raymond, Y. J. Cell Biol. (1987) [Pubmed]
  2. Ataxin-3 is transported into the nucleus and associates with the nuclear matrix. Tait, D., Riccio, M., Sittler, A., Scherzinger, E., Santi, S., Ognibene, A., Maraldi, N.M., Lehrach, H., Wanker, E.E. Hum. Mol. Genet. (1998) [Pubmed]
  3. Altered expression and localization of creatine kinase B, heterogeneous nuclear ribonucleoprotein F, and high mobility group box 1 protein in the nuclear matrix associated with colon cancer. Balasubramani, M., Day, B.W., Schoen, R.E., Getzenberg, R.H. Cancer Res. (2006) [Pubmed]
  4. In vivo DNA-protein cross-linking by cis- and trans-diamminedichloroplatinum(II). Olinski, R., Wedrychowski, A., Schmidt, W.N., Briggs, R.C., Hnilica, L.S. Cancer Res. (1987) [Pubmed]
  5. Expression of a highly conserved protein, p27BBP, during the progression of human colorectal cancer. Sanvito, F., Vivoli, F., Gambini, S., Santambrogio, G., Catena, M., Viale, E., Veglia, F., Donadini, A., Biffo, S., Marchisio, P.C. Cancer Res. (2000) [Pubmed]
  6. Polycomb and trithorax group proteins mediate the function of a chromatin insulator. Gerasimova, T.I., Corces, V.G. Cell (1998) [Pubmed]
  7. Chromosomal ARS and CEN elements bind specifically to the yeast nuclear scaffold. Amati, B.B., Gasser, S.M. Cell (1988) [Pubmed]
  8. The nuclear matrix: three-dimensional architecture and protein composition. Capco, D.G., Wan, K.M., Penman, S. Cell (1982) [Pubmed]
  9. The ovalbumin gene is associated with the nuclear matrix of chicken oviduct cells. Robinson, S.I., Nelkin, B.D., Vogelstein, B. Cell (1982) [Pubmed]
  10. Association of polyoma T antigen and DNA with the nuclear matrix from lytically infected 3T6 cells. Buckler-White, A.J., Humphrey, G.W., Pigiet, V. Cell (1980) [Pubmed]
  11. Inhibition of prostate cancer growth by estramustine and etoposide: evidence for interaction at the nuclear matrix. Pienta, K.J., Lehr, J.E. J. Urol. (1993) [Pubmed]
  12. Subnuclear localization of S/MAR-binding proteins is differently affected by in vitro stabilization with heat or Cu2+. Neri, L.M., Fackelmayer, F.O., Zweyer, M., Kohwi-Shigematsu, T., Martelli, A.M. Chromosoma (1997) [Pubmed]
  13. Spatial distribution of lamin A and B1 in the K562 cell nuclear matrix stabilized with metal ions. Neri, L.M., Raymond, Y., Giordano, A., Borgatti, P., Marchisio, M., Capitani, S., Martelli, A.M. J. Cell. Biochem. (1999) [Pubmed]
  14. Fragmentation of 'nuclear matrix' on a mica target. Müller, M., Spiess, E., Werner, D. Eur. J. Cell Biol. (1983) [Pubmed]
  15. Identification and immunocharacterization of a 25K structural protein in Autographa californica nuclear polyhedrosis virus (AcMNPV). Goh, D.K. Virus Res. (1993) [Pubmed]
  16. The transcriptional repressor CDP (Cutl1) is essential for epithelial cell differentiation of the lung and the hair follicle. Ellis, T., Gambardella, L., Horcher, M., Tschanz, S., Capol, J., Bertram, P., Jochum, W., Barrandon, Y., Busslinger, M. Genes Dev. (2001) [Pubmed]
  17. The matrix attachment regions of the chicken lysozyme gene co-map with the boundaries of the chromatin domain. Loc, P.V., Strätling, W.H. EMBO J. (1988) [Pubmed]
  18. The A-kinase-anchoring protein AKAP95 is a multivalent protein with a key role in chromatin condensation at mitosis. Collas, P., Le Guellec, K., Taskén, K. J. Cell Biol. (1999) [Pubmed]
  19. Structure, subnuclear distribution, and nuclear matrix association of the mammalian telomeric complex. Ludérus, M.E., van Steensel, B., Chong, L., Sibon, O.C., Cremers, F.F., de Lange, T. J. Cell Biol. (1996) [Pubmed]
  20. nup1 mutants exhibit pleiotropic defects in nuclear pore complex function. Bogerd, A.M., Hoffman, J.A., Amberg, D.C., Fink, G.R., Davis, L.I. J. Cell Biol. (1994) [Pubmed]
  21. A kinase-anchoring protein (AKAP)95 recruits human chromosome-associated protein (hCAP)-D2/Eg7 for chromosome condensation in mitotic extract. Steen, R.L., Cubizolles, F., Le Guellec, K., Collas, P. J. Cell Biol. (2000) [Pubmed]
  22. Association of transcriptionally active vitellogenin II gene with the nuclear matrix of chicken liver. Jost, J.P., Seldran, M. EMBO J. (1984) [Pubmed]
  23. The nuclear matrix protein, numatrin (B23), is associated with growth factor-induced mitogenesis in Swiss 3T3 fibroblasts and with T lymphocyte proliferation stimulated by lectins and anti-T cell antigen receptor antibody. Feuerstein, N., Spiegel, S., Mond, J.J. J. Cell Biol. (1988) [Pubmed]
  24. Association of simian virus 40 T antigen with the nuclear matrix of infected and transformed monkey cells. Covey, L., Choi, Y., Prives, C. Mol. Cell. Biol. (1984) [Pubmed]
  25. Steroid hormone regulation of nuclear proto-oncogenes. Schuchard, M., Landers, J.P., Sandhu, N.P., Spelsberg, T.C. Endocr. Rev. (1993) [Pubmed]
  26. A coactivator of pre-mRNA splicing. Blencowe, B.J., Issner, R., Nickerson, J.A., Sharp, P.A. Genes Dev. (1998) [Pubmed]
  27. FRAP reveals that mobility of oestrogen receptor-alpha is ligand- and proteasome-dependent. Stenoien, D.L., Patel, K., Mancini, M.G., Dutertre, M., Smith, C.L., O'Malley, B.W., Mancini, M.A. Nat. Cell Biol. (2001) [Pubmed]
  28. Core filaments of the nuclear matrix. He, D.C., Nickerson, J.A., Penman, S. J. Cell Biol. (1990) [Pubmed]
  29. Mapping replicational sites in the eucaryotic cell nucleus. Nakayasu, H., Berezney, R. J. Cell Biol. (1989) [Pubmed]
  30. XIST RNA paints the inactive X chromosome at interphase: evidence for a novel RNA involved in nuclear/chromosome structure. Clemson, C.M., McNeil, J.A., Willard, H.F., Lawrence, J.B. J. Cell Biol. (1996) [Pubmed]
  31. Nuclear Translocation of fibroblast growth factor (FGF) receptors in response to FGF-2. Maher, P.A. J. Cell Biol. (1996) [Pubmed]
  32. The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNA. Ohtsubo, M., Okazaki, H., Nishimoto, T. J. Cell Biol. (1989) [Pubmed]
  33. Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBF-alpha transcription factors. Zeng, C., van Wijnen, A.J., Stein, J.L., Meyers, S., Sun, W., Shopland, L., Lawrence, J.B., Penman, S., Lian, J.B., Stein, G.S., Hiebert, S.W. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  34. Genomic imprinting controls matrix attachment regions in the Igf2 gene. Weber, M., Hagège, H., Murrell, A., Brunel, C., Reik, W., Cathala, G., Forné, T. Mol. Cell. Biol. (2003) [Pubmed]
  35. Altered profiles in nuclear matrix proteins associated with DNA in situ during progression of breast cancer cells. Spencer, V.A., Samuel, S.K., Davie, J.R. Cancer Res. (2001) [Pubmed]
  36. Nuclear accumulation of fibroblast growth factor receptors is regulated by multiple signals in adrenal medullary cells. Stachowiak, M.K., Maher, P.A., Joy, A., Mordechai, E., Stachowiak, E.K. Mol. Biol. Cell (1996) [Pubmed]
  37. Calmodulin-binding proteins in the nuclei of quiescent and proliferatively activated rat liver cells. Bachs, O., Lanini, L., Serratosa, J., Coll, M.J., Bastos, R., Aligué, R., Rius, E., Carafoli, E. J. Biol. Chem. (1990) [Pubmed]
  38. The association of the interspersed repetitive KpnI sequences with the nuclear matrix. Chimera, J.A., Musich, P.R. J. Biol. Chem. (1985) [Pubmed]
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