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Gene Review:

SRRM2 - serine/arginine repetitive matrix 2

Homo sapiens

Synonyms: 300 kDa nuclear matrix antigen, 300-KD, CWF21, Cwc21, HSPC075, ...

Blencowe, B.J. et al., Blencowe, B.J. et al., Zimowska, G. et al., Youn, H.G. et al., Sawada, Y. et al.

Sawada, Miura, Umeki, Tamaoki, Fujinaga, Ohtaki,

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High impact information on SRRM2

SRm160 and a related protein SRm300 (the 300-kD nuclear matrix antigen recognized by mAb B4A11) form a complex that is required for the splicing of specific pre-mRNAs [1].
SR-related protein TAXREB803/SRL300 is an important cellular factor for the transactivational function of human T-cell lymphotropic virus type 1 Tax [2].
The deduced protein, termed SRL300, contains a unique RNA-binding region, two large RS domains and many phosphorylation sites [3].

Anatomical context of SRRM2

Three SR-rich proteins were identified that interact with the C-terminus of Pnn: SRp75 and SRm300, known components of spliceosome machinery, and a novel 130-kDa nuclear protein, SRrp130 [4].
The results suggest that a complex of the nuclear matrix proteins SRm160 and SRm300 functions as a coactivator of pre-mRNA splicing [1].

Associations of SRRM2 with chemical compounds

Like SRm160, the 300-kDa antigen contains domains rich in alternating S and R residues but lacks an RNA recognition motif; the protein is accordingly named "SRm300." SRm300 also contains a novel and highly conserved N-terminal domain, several unique repeated motifs rich in S, R, and proline residues, and two very long polyserine tracts [5].

References

A coactivator of pre-mRNA splicing. Blencowe, B.J., Issner, R., Nickerson, J.A., Sharp, P.A. Genes Dev. (1998) [Pubmed]
SR-related protein TAXREB803/SRL300 is an important cellular factor for the transactivational function of human T-cell lymphotropic virus type 1 Tax. Youn, H.G., Matsumoto, J., Tanaka, Y., Shimotohno, K. J. Virol. (2003) [Pubmed]
Cloning and characterization of a novel RNA-binding protein SRL300 with RS domains. Sawada, Y., Miura, Y., Umeki, K., Tamaoki, T., Fujinaga, K., Ohtaki, S. Biochim. Biophys. Acta (2000) [Pubmed]
Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells. Zimowska, G., Shi, J., Munguba, G., Jackson, M.R., Alpatov, R., Simmons, M.N., Shi, Y., Sugrue, S.P. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
The SRm160/300 splicing coactivator subunits. Blencowe, B.J., Baurén, G., Eldridge, A.G., Issner, R., Nickerson, J.A., Rosonina, E., Sharp, P.A. RNA (2000) [Pubmed]

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