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Gene Review

PNISR  -  PNN-interacting serine/arginine-rich protein

Homo sapiens

Synonyms: Arginine/serine-rich protein PNISR, C6orf111, DKFZp564B0769, FLJ14752, HSPC261, ...
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Disease relevance of C6orf111


High impact information on C6orf111

  • The nuclear matrix antigen recognized by the monoclonal antibody (mAb) B1C8 is a novel serine (S) and arginine (R)-rich protein associated with splicing complexes and is named here SRm160 (SR-related matrix protein of 160 kD) [3].
  • This novel protein possesses an arginine- and serine-rich domain and was termed SRrp53 (for SR-related protein of 53 kDa) [4].
  • In failing human myocytes, Ca2+ transients and contractions exhibit an SR-related, phasic component and a slow, reverse-mode Na+/Ca2+ exchange-related tonic component [5].
  • Using reverse transcription-PCR, we found evidence of expression in hematopoietic cells for 3 of 15 genes in the region (GRIK2, C6orf111, and CCNC) [6].
  • Despite showing an involvement in splicing, we detected no stable interaction between SAFB proteins and SR or SR-related splicing regulators, although these were also found in stable higher molecular mass complexes [7].

Biological context of C6orf111

  • These findings offer the first example in fission yeast for interactions between SR-related proteins and the modulation of the interactions by specific protein phosphorylation, suggesting that a mammalian-like SR protein function may exist in fission yeast [8].
  • Multiple transcripts encoding serine-arginine rich (SR) and SR-related splicing regulators were suppressed in cells expressing either of these variants, whereas the gene groups including splicing-related helicases and transcripts involved in apoptosis displayed variant-specific changes [9].
  • We have thus shown that the spliceosomal component XE7 resembles an SR-related splicing protein, and can influence alternative splicing [10].

Anatomical context of C6orf111

  • Three SR-rich proteins were identified that interact with the C-terminus of Pnn: SRp75 and SRm300, known components of spliceosome machinery, and a novel 130-kDa nuclear protein, SRrp130 [11].
  • SR-related protein TAXREB803/SRL300 is an important cellular factor for the transactivational function of human T-cell lymphotropic virus type 1 Tax [12].

Associations of C6orf111 with chemical compounds

  • Analysis of the Pnn motifs using two-hybrid system assays demonstrated that the polyserine/RS motif within Pnn plays a central but not exclusive role in mediating molecular interactions with identified SR-rich proteins [11].
  • TAXREB803 is an SR-related protein composed of 2,752 amino acids including numerous arginine/serine (RS) motifs [12].

Physical interactions of C6orf111


Other interactions of C6orf111


Analytical, diagnostic and therapeutic context of C6orf111

  • Expression levels of SR and SR-related proteins in Pnn-depleted cells as compared to those in control cells were evaluated by immunofluorescent staining and Western blot with specific antibodies [19].


  1. Prognostic significance of the expression of SR-A1, encoding a novel SR-related CTD-associated factor, in breast cancer. Leoutsakou, T., Talieri, M., Scorilas, A. Biol. Chem. (2006) [Pubmed]
  2. Anti-IgG antibodies in rheumatic diseases cross-react with Streptococcus mutans SR antigen. Ackermans, F., Pini, A., Wachsmann, D., Schöller, M., Ogier, J., Klein, J.P. Clin. Exp. Immunol. (1991) [Pubmed]
  3. A coactivator of pre-mRNA splicing. Blencowe, B.J., Issner, R., Nickerson, J.A., Sharp, P.A. Genes Dev. (1998) [Pubmed]
  4. A novel SR-related protein is required for the second step of Pre-mRNA splicing. Cazalla, D., Newton, K., Cáceres, J.F. Mol. Cell. Biol. (2005) [Pubmed]
  5. The sarcoplasmic reticulum and the Na+/Ca2+ exchanger both contribute to the Ca2+ transient of failing human ventricular myocytes. Dipla, K., Mattiello, J.A., Margulies, K.B., Jeevanandam, V., Houser, S.R. Circ. Res. (1999) [Pubmed]
  6. A fluorescence in situ hybridization map of 6q deletions in acute lymphocytic leukemia: identification and analysis of a candidate tumor suppressor gene. Sinclair, P.B., Sorour, A., Martineau, M., Harrison, C.J., Mitchell, W.A., O'Neill, E., Foroni, L. Cancer Res. (2004) [Pubmed]
  7. Alternative RNA splicing complexes containing the scaffold attachment factor SAFB2. Sergeant, K.A., Bourgeois, C.F., Dalgliesh, C., Venables, J.P., Stevenin, J., Elliott, D.J. J. Cell. Sci. (2007) [Pubmed]
  8. Interactions between two fission yeast serine/arginine-rich proteins and their modulation by phosphorylation. Tang, Z., Käufer, N.F., Lin, R.J. Biochem. J. (2002) [Pubmed]
  9. Modulated splicing-associated gene expression in P19 cells expressing distinct acetylcholinesterase splice variants. Ben-Ari, S., Toiber, D., Sas, A.S., Soreq, H., Ben-Shaul, Y. J. Neurochem. (2006) [Pubmed]
  10. XE7: a novel splicing factor that interacts with ASF/SF2 and ZNF265. Mangs, A.H., Speirs, H.J., Goy, C., Adams, D.J., Markus, M.A., Morris, B.J. Nucleic Acids Res. (2006) [Pubmed]
  11. Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells. Zimowska, G., Shi, J., Munguba, G., Jackson, M.R., Alpatov, R., Simmons, M.N., Shi, Y., Sugrue, S.P. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  12. SR-related protein TAXREB803/SRL300 is an important cellular factor for the transactivational function of human T-cell lymphotropic virus type 1 Tax. Youn, H.G., Matsumoto, J., Tanaka, Y., Shimotohno, K. J. Virol. (2003) [Pubmed]
  13. A novel SR-related protein specifically interacts with the carboxy-terminal domain (CTD) of RNA polymerase II through a conserved interaction domain. Tanner, S., Stagljar, I., Georgiev, O., Schaffner, W., Bourquin, J.P. Biol. Chem. (1997) [Pubmed]
  14. Over-expression of SR-cyclophilin, an interaction partner of nuclear pinin, releases SR family splicing factors from nuclear speckles. Lin, C.L., Leu, S., Lu, M.C., Ouyang, P. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  15. SF4 and SFRS14, two related putative splicing factors on human chromosome 19p13.11. Sampson, N.D., Hewitt, J.E. Gene (2003) [Pubmed]
  16. CIR, a corepressor of CBF1, binds to PAP-1 and effects alternative splicing. Maita, H., Kitaura, H., Ariga, H., Iguchi-Ariga, S.M. Exp. Cell Res. (2005) [Pubmed]
  17. Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/Luc7A. Umehara, H., Nishii, Y., Morishima, M., Kakehi, Y., Kioka, N., Amachi, T., Koizumi, J., Hagiwara, M., Ueda, K. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  18. Effects of Scutellariae Radix on gene expression in HEK 293 cells using cDNA microarray. Chen, C.S., Chen, N.J., Lin, L.W., Hsieh, C.C., Chen, G.W., Hsieh, M.T. Journal of ethnopharmacology. (2006) [Pubmed]
  19. Loss of Pnn expression attenuates expression levels of SR family splicing factors and modulates alternative pre-mRNA splicing in vivo. Chiu, Y., Ouyang, P. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
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