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Gene Review:

Lingo1 - leucine rich repeat and Ig domain...

Mus musculus

Synonyms: 4930471K13Rik, AV148400, LERN1, LINGO-1, Lern1, ...

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Lingo1

We show that loss of LINGO-1 function by Lingo1 gene knockout or by treatment with an antibody antagonist of LINGO-1 function leads to functional recovery from experimental autoimmune encephalomyelitis [1].

High impact information on Lingo1

LINGO-1 is expressed in oligodendrocytes [2].
Attenuation of LINGO-1 results in downregulation of RhoA activity, which has been implicated in oligodendrocyte differentiation [2].

References

LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis. Mi, S., Hu, B., Hahm, K., Luo, Y., Kam Hui, E.S., Yuan, Q., Wong, W.M., Wang, L., Su, H., Chu, T.H., Guo, J., Zhang, W., So, K.F., Pepinsky, B., Shao, Z., Graff, C., Garber, E., Jung, V., Wu, E.X., Wu, W. Nat. Med. (2007) [Pubmed]
LINGO-1 negatively regulates myelination by oligodendrocytes. Mi, S., Miller, R.H., Lee, X., Scott, M.L., Shulag-Morskaya, S., Shao, Z., Chang, J., Thill, G., Levesque, M., Zhang, M., Hession, C., Sah, D., Trapp, B., He, Z., Jung, V., McCoy, J.M., Pepinsky, R.B. Nat. Neurosci. (2005) [Pubmed]

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LINGO1	Bos taurus
LINGO1	Canis lupus familiaris
lingo1a	Danio rerio
LINGO1	Gallus gallus
LINGO1	Homo sapiens
LINGO1	Macaca mulatta
LINGO1	Pan troglodytes
Lingo1	Rattus norvegicus
lingo1	Xenopus (Silurana) tropicalis

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