Psychiatry related information on LINGO1

High impact information on LINGO1

• A dominant-negative human LINGO-1 construct attenuated myelin inhibition in transfected primary neuronal cultures [1].
• Nogo receptor (NgR)-mediated control of axon growth relies on the central nervous system-specific type I transmembrane protein Lingo-1 [2].
• In addition, the inhibitory role of Lingo-1 is particularly important in regulation of oligodendrocyte differentiation and myelination, suggesting that pharmacological modulation of Lingo-1 function could be a novel approach for nerve repair and remyelination therapies [2].
• The structure of the lingo-1 ectodomain, a module implicated in central nervous system repair inhibition [2].
• Interactions between Lingo-1 and NgR, along with a complementary co-receptor, result in neurite and axonal collapse [2].

Biological context of LINGO1

• Taken together, the confirmation of LRRN6A's expression profile, its predicted protein structure and its similarity to nervous system-expressed LRR proteins with essential roles in nervous system development and maintenance suggest that LRRN6A is a novel gene of relevance in the molecular and cellular neurobiology of vertebrates [3].
• The identification of homologous genes to LRRN6A on chromosomes 9 and 19 and the orthologous genes in the mouse genome and other organisms suggests that LERN proteins constitute a novel subfamily of LRR (leucine-rich repeat)-containing proteins [3].

Anatomical context of LINGO1

• The LRRN6A expression pattern is specific to the central nervous system, highly and broadly expressed during early stages of development and gradually restricted to forebrain structures as development proceeds [3].
• LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene with enriched expression in limbic system and neocortex [3].
• Real-time PCR showed maximum expression of AKL, LRRN6A, and T-cell receptor gamma (TCR-gamma)-like genes in the testis, SMOC-1 in the liver, and the T-cell receptor-like (TCRL) gene in the spleen compared to those used as endogenous control [4].
• TROY and LINGO-1 were identified in subpopulations of reactive astrocytes, macrophages/microglia and neurones but not in oligodendrocytes [5].
• TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions [5].

Physical interactions of LINGO1

• Here, we identify LRR and Ig domain-containing, Nogo receptor-interacting protein (LINGO-1) as a potent axonal inhibitor of oligodendrocyte differentiation and myelination that is regulated by nerve growth factor and its cognate receptor TrkA in a dose-dependent manner [6].

Other interactions of LINGO1

• TROY was up-regulated, whereas LINGO-1 was reduced in MS brains by Western blot [5].
• Furthermore, these results were recapitulated in transgenic mice overexpressing the full length LINGO-1 under the neuronal promoter synapsin [6].

References