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Gene Review

LINGO1  -  leucine rich repeat and Ig domain...

Homo sapiens

Synonyms: FLJ14594, LERN1, LRRN6A, Leucine-rich repeat and immunoglobulin domain-containing protein 1, Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1, ...
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Psychiatry related information on LINGO1


High impact information on LINGO1

  • A dominant-negative human LINGO-1 construct attenuated myelin inhibition in transfected primary neuronal cultures [1].
  • Nogo receptor (NgR)-mediated control of axon growth relies on the central nervous system-specific type I transmembrane protein Lingo-1 [2].
  • In addition, the inhibitory role of Lingo-1 is particularly important in regulation of oligodendrocyte differentiation and myelination, suggesting that pharmacological modulation of Lingo-1 function could be a novel approach for nerve repair and remyelination therapies [2].
  • The structure of the lingo-1 ectodomain, a module implicated in central nervous system repair inhibition [2].
  • Interactions between Lingo-1 and NgR, along with a complementary co-receptor, result in neurite and axonal collapse [2].

Biological context of LINGO1

  • Taken together, the confirmation of LRRN6A's expression profile, its predicted protein structure and its similarity to nervous system-expressed LRR proteins with essential roles in nervous system development and maintenance suggest that LRRN6A is a novel gene of relevance in the molecular and cellular neurobiology of vertebrates [3].
  • The identification of homologous genes to LRRN6A on chromosomes 9 and 19 and the orthologous genes in the mouse genome and other organisms suggests that LERN proteins constitute a novel subfamily of LRR (leucine-rich repeat)-containing proteins [3].

Anatomical context of LINGO1


Physical interactions of LINGO1

  • Here, we identify LRR and Ig domain-containing, Nogo receptor-interacting protein (LINGO-1) as a potent axonal inhibitor of oligodendrocyte differentiation and myelination that is regulated by nerve growth factor and its cognate receptor TrkA in a dose-dependent manner [6].

Other interactions of LINGO1


  1. LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex. Mi, S., Lee, X., Shao, Z., Thill, G., Ji, B., Relton, J., Levesque, M., Allaire, N., Perrin, S., Sands, B., Crowell, T., Cate, R.L., McCoy, J.M., Pepinsky, R.B. Nat. Neurosci. (2004) [Pubmed]
  2. The structure of the lingo-1 ectodomain, a module implicated in central nervous system repair inhibition. Mosyak, L., Wood, A., Dwyer, B., Buddha, M., Johnson, M., Aulabaugh, A., Zhong, X., Presman, E., Benard, S., Kelleher, K., Wilhelm, J., Stahl, M.L., Kriz, R., Gao, Y., Cao, Z., Ling, H.P., Pangalos, M.N., Walsh, F.S., Somers, W.S. J. Biol. Chem. (2006) [Pubmed]
  3. LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene with enriched expression in limbic system and neocortex. Carim-Todd, L., Escarceller, M., Estivill, X., Sumoy, L. Eur. J. Neurosci. (2003) [Pubmed]
  4. Transcriptional status of known and novel genes tagged with consensus of 33.15 repeat loci employing minisatellite-associated sequence amplification (MASA) and real-time PCR in water buffalo, Bubalus bubalis. Srivastava, J., Premi, S., Pathak, D., Ahsan, Z., Tiwari, M., Garg, L.C., Ali, S. DNA Cell Biol. (2006) [Pubmed]
  5. TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions. Satoh, J., Tabunoki, H., Yamamura, T., Arima, K., Konno, H. Neuropathol. Appl. Neurobiol. (2007) [Pubmed]
  6. NGF regulates the expression of axonal LINGO-1 to inhibit oligodendrocyte differentiation and myelination. Lee, X., Yang, Z., Shao, Z., Rosenberg, S.S., Levesque, M., Pepinsky, R.B., Qiu, M., Miller, R.H., Chan, J.R., Mi, S. J. Neurosci. (2007) [Pubmed]
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