The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

TSPAN12  -  tetraspanin 12

Homo sapiens

Synonyms: EVR5, NET-2, NET2, TM4SF12, Tetraspan NET-2, ...
 
 
 

Disease related information for TSPAN12

 

  • TSPAN12 frameshift, deletion and point mutations have been found in patients exhibiting Familial Exudative Vintreo-Retinopathy (FEVR) [1]
 

High impact information on TSPAN12

  • To overcome this problem, we designed a second network, NET2, which learned to determine when NET1 was in a state of generalization [2].
  • We characterized the two major isoforms of human NET, hNET1, which has seven C-terminal amino acids encoded by exon 15, and hNET2, which has 18 amino acids encoded by exon 16, by site-directed mutagenesis in combination with NE (noradrenaline) uptake assays and cell surface biotinylation [3].
  • Replacement of RRR, an endoplasmic reticulum retention motif, by alanine residues in the C-terminus of hNET2 resulted in a similar expression and function compared with the WT, while partly recovering the effects of the mutation of ENE [3].

 

 

 

References

  1. Novel TSPAN12 mutations in patients with familial exudative vitreoretinopathy and their associated phenotypes. Yang, H., Xiao, X., Li, S., Mai, G., Zhang, Q. Mol. Vis. (2011) [Pubmed]
  2. Predicting protein secondary structure content. A tandem neural network approach. Muskal, S.M., Kim, S.H. J. Mol. Biol. (1992) [Pubmed]
  3. C-terminal region regulates the functional expression of human noradrenaline transporter splice variants. Sogawa, C., Kumagai, K., Sogawa, N., Morita, K., Dohi, T., Kitayama, S. Biochem. J. (2007) [Pubmed]
 
WikiGenes - Universities