Gene Review:
SLC6A2 - solute carrier family 6 (neurotransmitter...
Homo sapiens
Synonyms:
NAT1, NET, NET1, Norepinephrine transporter, SLC6A5, ...
van den Maagdenberg,
Rees,
Russell,
Stephenson,
Kübler,
Zitzmann,
Owen,
Hohoff,
Lesch,
Freitag,
Neve,
Urwin,
Chung,
Wilcken,
Bennetts,
Dmitrzak-Weglarz,
Fimmers,
Douglas,
Smart,
Czerski,
Eshleman,
Wilcken,
Nunn,
Sand,
Haberkorn,
Biederman,
Michelson,
Manasco,
Reimherr,
Kapelski,
Martens,
Hauser,
Cumbay,
Faraone,
Spencer,
Mahmut,
Supplisson,
Thomas,
Deckert,
Graham,
Godlewski,
Rothe,
Armstrong,
Gutknecht,
Altmann,
Shiang,
Nunn,
Pearce,
Abbott,
Peschke,
Ouyang,
Dow,
Beatty,
Tijssen,
Kissel,
Lee,
Pablo,
Harvey,
Carmolli,
Mash,
Beumont,
Glatt,
Ravna,
Roses,
Harvey,
Tanner,
Urwin,
Qin,
Pillai,
Zuberi,
Duguid,
Bennetts,
Stubbins,
Domschke,
Russell,
McCarthy,
Lampropoulos,
Rybakowski,
Adler,
Janowsky,
Spraggs,
Sieber-Blum,
Beumont,
Leszczyńska-Rodziewicz,
- Epidemiological evidence of an association between SLC6A2 gene polymorphism and hypertension. Ono, K., Iwanaga, Y., Mannami, T., Kokubo, Y., Tomoike, H., Komamura, K., Shioji, K., Yasui, N., Tago, N., Iwai, N. Hypertens. Res. (2003)
- Proteomic analysis of human norepinephrine transporter complexes reveals associations with protein phosphatase 2A anchoring subunit and 14-3-3 proteins. Sung, U., Jennings, J.L., Link, A.J., Blakely, R.D. Biochem. Biophys. Res. Commun. (2005)
- Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency. Shannon, J.R., Flattem, N.L., Jordan, J., Jacob, G., Black, B.K., Biaggioni, I., Blakely, R.D., Robertson, D. N. Engl. J. Med. (2000)
- Molecular cloning and organization of the coding region of the human norepinephrine transporter gene. Pörzgen, P., Bönisch, H., Brüss, M. Biochem. Biophys. Res. Commun. (1995)
- Pharmacogenetics and obesity: common gene variants influence weight loss response of the norepinephrine/dopamine transporter inhibitor GW320659 in obese subjects. Spraggs, C.F., Pillai, S.G., Dow, D., Douglas, C., McCarthy, L., Manasco, P.K., Stubbins, M., Roses, A.D. Pharmacogenet. Genomics (2005)
- Gene-gene interaction between the monoamine oxidase A gene and solute carrier family 6 (neurotransmitter transporter, noradrenalin) member 2 gene in anorexia nervosa (restrictive subtype). Urwin, R.E., Bennetts, B.H., Wilcken, B., Lampropoulos, B., Beumont, P.J., Russell, J.D., Tanner, S.L., Nunn, K.P. Eur. J. Hum. Genet. (2003)
- Three-dimensional models of neurotransmitter transporters and their interactions with cocaine and S-citalopram. Ravna, A.W. World J. Biol. Psychiatry (2006)
- Substrate binding stoichiometry and kinetics of the norepinephrine transporter. Schwartz, J.W., Novarino, G., Piston, D.W., DeFelice, L.J. J. Biol. Chem. (2005)
- Norepinephrine transporter (NET) promoter and 5'-UTR polymorphisms: association analysis in panic disorder. Lee, Y.J., Hohoff, C., Domschke, K., Sand, P., Kuhlenbäumer, G., Schirmacher, A., Freitag, C.M., Meyer, J., Stöber, G., Franke, P., Nöthen, M.M., Fritze, J., Fimmers, R., Garritsen, H.S., Stögbauer, F., Deckert, J. Neurosci. Lett. (2005)
- A polymorphism of the norepinephrine transporter gene in bipolar disorder and schizophrenia: lack of association. Leszczyńska-Rodziewicz, A., Czerski, P.M., Kapelski, P., Godlewski, S., Dmitrzak-Weglarz, M., Rybakowski, J., Hauser, J. Neuropsychobiology (2002)
- Mutations in the gene encoding GlyT2 (SLC6A5) define a presynaptic component of human startle disease. Rees, M.I., Harvey, K., Pearce, B.R., Chung, S.K., Duguid, I.C., Thomas, P., Beatty, S., Graham, G.E., Armstrong, L., Shiang, R., Abbott, K.J., Zuberi, S.M., Stephenson, J.B., Owen, M.J., Tijssen, M.A., van den Maagdenberg, A.M., Smart, T.G., Supplisson, S., Harvey, R.J. Nat. Genet. (2006)
- Nonclassical, distinct endocytic signals dictate constitutive and PKC-regulated neurotransmitter transporter internalization. Holton, K.L., Loder, M.K., Melikian, H.E. Nat. Neurosci. (2005)
- Investigation of epistasis between the serotonin transporter and norepinephrine transporter genes in anorexia nervosa. Urwin, R.E., Bennetts, B.H., Wilcken, B., Beumont, P.J., Russell, J.D., Nunn, K.P. Neuropsychopharmacology (2003)
- Influence of sibutramine treatment on sympathetic vasomotor tone in obese subjects. Heusser, K., Tank, J., Diedrich, A., Engeli, S., Klaua, S., Krüger, N., Strauss, A., Stoffels, G., Luft, F.C., Jordan, J. Clin. Pharmacol. Ther. (2006)
- Atomoxetine and adult attention-deficit/hyperactivity disorder: the effects of comorbidity. Spencer, T.J., Faraone, S.V., Michelson, D., Adler, L.A., Reimherr, F.W., Glatt, S.J., Biederman, J. The Journal of clinical psychiatry. (2006)
- Increased MIBG uptake after transfer of the human norepinephrine transporter gene in rat hepatoma. Altmann, A., Kissel, M., Zitzmann, S., Kübler, W., Mahmut, M., Peschke, P., Haberkorn, U. J. Nucl. Med. (2003)
- Support for association between ADHD and two candidate genes: NET1 and DRD1. Bobb, A.J., Addington, A.M., Sidransky, E., Gornick, M.C., Lerch, J.P., Greenstein, D.K., Clasen, L.S., Sharp, W.S., Inoff-Germain, G., Wavrant-De Vrièze, F., Arcos-Burgos, M., Straub, R.E., Hardy, J.A., Castellanos, F.X., Rapoport, J.L. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2005)
- A previously undescribed intron and extensive 5' upstream sequence, but not Phox2a-mediated transactivation, are necessary for high level cell type-specific expression of the human norepinephrine transporter gene. Kim, C.H., Kim, H.S., Cubells, J.F., Kim, K.S. J. Biol. Chem. (1999)
- Studies of the biogenic amine transporters. XI. Identification of a 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR12909) analog that allosterically modulates the serotonin transporter. Nightingale, B., Dersch, C.M., Boos, T.L., Greiner, E., Calhoun, W.J., Jacobson, A.E., Rice, K.C., Rothman, R.B. J. Pharmacol. Exp. Ther. (2005)
- Functional importance of the C-terminus of the human norepinephrine transporter. Distelmaier, F., Wiedemann, P., Brüss, M., Bönisch, H. J. Neurochem. (2004)
- Acute regulation of norepinephrine transport: II. PKC-modulated surface expression of human norepinephrine transporter proteins. Apparsundaram, S., Schroeter, S., Giovanetti, E., Blakely, R.D. J. Pharmacol. Exp. Ther. (1998)
- Transporter-mediated actions of R-(-)-1-(benzofuran-2-yl)-2-propylaminopentane. Shimazu, S., Tsunekawa, H., Yoneda, F., Katsuki, H., Akaike, A., Janowsky, A. Eur. J. Pharmacol. (2003)
- Dopamine and norepinephrine transporter-dependent c-Fos production in vitro: relevance to neuroadaptation. Yatin, S.M., Miller, G.M., Madras, B.K. J. Neurosci. Methods (2005)
- Functional consequences of homo- but not hetero-oligomerization between transporters for the biogenic amine neurotransmitters. Kocabas, A.M., Rudnick, G., Kilic, F. J. Neurochem. (2003)
- Norepinephrine transporter gene variation modulates acute response to D-amphetamine. Dlugos, A., Freitag, C., Hohoff, C., McDonald, J., Cook, E.H., Deckert, J., de Wit, H. Biol. Psychiatry (2007)
- Characteristics of drug interactions with recombinant biogenic amine transporters expressed in the same cell type. Eshleman, A.J., Carmolli, M., Cumbay, M., Martens, C.R., Neve, K.A., Janowsky, A. J. Pharmacol. Exp. Ther. (1999)
- Effects of long-term cigarette smoking on the human locus coeruleus. Klimek, V., Zhu, M.Y., Dilley, G., Konick, L., Overholser, J.C., Meltzer, H.Y., May, W.L., Stockmeier, C.A., Ordway, G.A. Arch. Gen. Psychiatry (2001)
- Molecular modeling of potential new and selective PET radiotracers for the serotonin transporter. Positron Emission Tomography. Wellsow, J., Kovar, K.A., Machulla, H.J. Journal of pharmacy & pharmaceutical sciences [electronic resource] : a publication of the Canadian Society for Pharmaceutical Sciences, Société canadienne des sciences pharmaceutiques. (2002)
- A polymorphism in the norepinephrine transporter gene alters promoter activity and is associated with attention-deficit hyperactivity disorder. Kim, C.H., Hahn, M.K., Joung, Y., Anderson, S.L., Steele, A.H., Mazei-Robinson, M.S., Gizer, I., Teicher, M.H., Cohen, B.M., Robertson, D., Waldman, I.D., Blakely, R.D., Kim, K.S. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Opposing functions of GDNF and NGF in the development of cholinergic and noradrenergic sympathetic neurons. Brodski, C., Schaubmar, A., Dechant, G. Mol. Cell. Neurosci. (2002)
- Catechol-O-methyltransferase activity in CHO cells expressing norepinephrine transporter. Percy, E., Kaye, D.M., Lambert, G.W., Gruskin, S., Esler, M.D., Du, X.J. Br. J. Pharmacol. (1999)
- Positive association between T-182C polymorphism in the norepinephrine transporter gene and susceptibility to major depressive disorder in a japanese population. Inoue, K., Itoh, K., Yoshida, K., Shimizu, T., Suzuki, T. Neuropsychobiology (2004)
- Interaction of serotonergic and noradrenergic gene variants in panic disorder. Freitag, C.M., Domschke, K., Rothe, C., Lee, Y.J., Hohoff, C., Gutknecht, L., Sand, P., Fimmers, R., Lesch, K.P., Deckert, J. Psychiatr. Genet. (2006)
- Growth factor synergism and antagonism in early neural crest development. Sieber-Blum, M. Biochem. Cell Biol. (1998)
- Chromosomal mapping of the human gene for the tricyclic antidepressant-sensitive noradrenaline transporter. Brüss, M., Kunz, J., Lingen, B., Bönisch, H. Hum. Genet. (1993)
- Norepinephrine transporter immunoblotting and radioligand binding in cocaine abusers. Mash, D.C., Ouyang, Q., Qin, Y., Pablo, J. J. Neurosci. Methods (2005)
- A mutation in the human norepinephrine transporter gene (SLC6A2) associated with orthostatic intolerance disrupts surface expression of mutant and wild-type transporters. Hahn, M.K., Robertson, D., Blakely, R.D. J. Neurosci. (2003)