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Gene Review

ZIM2  -  zinc finger, imprinted 2

Homo sapiens

Synonyms: ZNF656, Zinc finger imprinted 2, Zinc finger protein 656
 
 
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High impact information on ZIM2

  • These observations are striking in light of the structural and functional conservation that typifies other imprinted domains and suggest that the PEG3/ZIM2 imprinted domain may have evolved in an unusual lineage-specific pattern [1].
  • Lineage-specific imprinting and evolution of the zinc-finger gene ZIM2 [1].
  • Alternative splicing events connect these 7 exons either with the remaining 2 exons of PEG3 or with the remaining 4 exons of ZIM2 [2].
  • ZIM2 produces two different-size transcripts, 2.5 and 9.0 kb in length, with highest levels of expression in adult testis and modest levels in fetal kidney and brain [2].
 

Biological context of ZIM2

  • Human ZIM2 and PEG3 share a set of 5' exons and a common promoter, and both genes are paternally expressed [1].
  • Sequencing of the 5'-termini of both transcripts indicates that ZIM2 and PEG3 share identical transcription start sites and may also share upstream regulatory elements, although the two genes show distinct patterns of tissue-specific expression [2].

References

  1. Lineage-specific imprinting and evolution of the zinc-finger gene ZIM2. Kim, J., Bergmann, A., Lucas, S., Stone, R., Stubbs, L. Genomics (2004) [Pubmed]
  2. Exon sharing of a novel human zinc-finger gene, ZIM2, and paternally expressed gene 3 (PEG3). Kim, J., Bergmann, A., Stubbs, L. Genomics (2000) [Pubmed]
 
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