Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Neu4 - sialidase 4

Mus musculus

Synonyms: N-acetyl-alpha-neuraminidase 4, Neuraminidase 4, Sialidase-4

Regl, G. et al., Comelli, E.M. et al.

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Disease relevance of Neu4

Analysis with free sialic acid derivatives revealed that the MHV-S HE protein specifically de-O-acetylates 5-N-acetyl-4-O-acetyl sialic acid (Neu4, 5Ac2) but not 5-N-acetyl-9-O-acetyl sialic acid (Neu5,9Ac2), which is the major substrate for esterases of influenza C virus and bovine coronaviruses [1].

High impact information on Neu4

A partial murine gene homologous to known mammalian sialidases reported in the Celera database is shown to encode a novel neuraminidase, designated as murine neuraminidase 4 (Neu4) [2].

References

The hemagglutinin-esterase of mouse hepatitis virus strain S is a sialate-4-O-acetylesterase. Regl, G., Kaser, A., Iwersen, M., Schmid, H., Kohla, G., Strobl, B., Vilas, U., Schauer, R., Vlasak, R. J. Virol. (1999) [Pubmed]
Identification and expression of Neu4, a novel murine sialidase. Comelli, E.M., Amado, M., Lustig, S.R., Paulson, J.C. Gene (2003) [Pubmed]

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