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Gene Review:

FRA13A - fragile site, aphidicolin type, common,...

Homo sapiens

Savelyeva, L. et al., Savelyeva, L. et al.

Savelyeva, Sagulenko, Schmitt, Schwab,

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High impact information on FRA13A

We show that FRA13A breaks are limited to a 650 kb region within the neurobeachin (NBEA) gene, which genomically spans approximately 730 kb [1].
According to the Genome Database, the common fragile site FRA13A maps to chromosome band 13q13 [1].
2. Here, we identify the precise genomic position of FRA13A, and characterize the genetic complexity of the fragile DNA sequence [1].

Anatomical context of FRA13A

In this review, we discuss the characterization of common fragile site FRA13A within the neurobeachin gene, which is involved in development and function of the central nervous system [2].

References

The neurobeachin gene spans the common fragile site FRA13A. Savelyeva, L., Sagulenko, E., Schmitt, J.G., Schwab, M. Hum. Genet. (2006) [Pubmed]
Low-frequency common fragile sites: link to neuropsychiatric disorders? Savelyeva, L., Sagulenko, E., Schmitt, J.G., Schwab, M. Cancer Lett. (2006) [Pubmed]

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