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Gene Review

Tox  -  thymocyte selection-associated high...

Mus musculus

Synonyms: 1700007F02Rik, Thymocyte selection-associated high mobility group box protein TOX, Thymus high mobility group box protein TOX
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Disease relevance of Tox

  • We used tissue culture cells and isogenic derivatives of a proline auxotrophic strain of E. coli that were fimbriated (Fim+) or nonfimbriated (Fim-), and were heat-labile enterotoxin producing (Tox+) or toxin nonproducing (Tox-) [1].

High impact information on Tox

  • Addition of subdamaging doses of exogenous toxin A to eyes infected with the Tox- mutant PA103-29 significantly increased is virulence [2].
  • After traumatization, corneas were infected with wild-type parental toxin A-producing strains, two toxin A-deficient mutants (Tox-), or an elastase mutant [2].

Analytical, diagnostic and therapeutic context of Tox

  • Using gene chip technology, we isolated a murine gene, designated Tox, that encodes a member of the HMG (high-mobility group) box family of DNA-binding proteins [3].


  1. Growth advantage and enhanced toxicity of Escherichia coli adherent to tissue culture cells due to restricted diffusion of products secreted by the cells. Zafriri, D., Oron, Y., Eisenstein, B.I., Ofek, I. J. Clin. Invest. (1987) [Pubmed]
  2. Corneal infections in mice with toxin A and elastase mutants of Pseudomonas aeruginosa. Ohman, D.E., Burns, R.P., Iglewski, B.H. J. Infect. Dis. (1980) [Pubmed]
  3. TOX: an HMG box protein implicated in the regulation of thymocyte selection. Wilkinson, B., Chen, J.Y., Han, P., Rufner, K.M., Goularte, O.D., Kaye, J. Nat. Immunol. (2002) [Pubmed]
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