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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Cyp3a18  -  cytochrome P450, family 3, subfamily a,...

Rattus norvegicus

Synonyms: CYPIIIA18, Cytochrome P450 3A18, Cytochrome P450(6)beta-2
 
 
 
 
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High impact information on Cyp3a18

  • Isolation and characterization of a new rat P450 (CYP3A18) cDNA encoding P450(6)beta-2 catalyzing testosterone 6 beta- and 16 alpha-hydroxylations [1].
  • Expressed CYP3A18 protein in COS-1 cells migrated at a position identical to that of purified P450(6)beta-2 on sodium dodecyl sulfate-acrylamide gel electrophoresis and catalyzed 16 beta- and 6 alpha-hydroxylations of testosterone [1].
  • A cytochrome P450 cDNA, encoding a new form of CYP3A protein, was isolated from a liver cDNA library of a male rat using anti-P450(6)beta-1 and anti-P450(6)beta-2 antibodies and the CYP3A2 cDNA [1].

References

  1. Isolation and characterization of a new rat P450 (CYP3A18) cDNA encoding P450(6)beta-2 catalyzing testosterone 6 beta- and 16 alpha-hydroxylations. Nagata, K., Murayama, N., Miyata, M., Shimada, M., Urahashi, A., Yamazoe, Y., Kato, R. Pharmacogenetics (1996) [Pubmed]
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