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Gene Review

rpb6  -  DNA-directed RNA polymerase I, II and III...

Schizosaccharomyces pombe 972h-

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High impact information on rpb6

  • Both 6AU sensitivity and temperature-sensitive phenotypes of these rpb6 mutants were suppressed by overexpression of TFIIS, a transcription elongation factor [1].
  • Deletion and truncation analyses of the rpb6 gene in the fission yeast Schizosaccharomyces pombe indicated that Rpb6, consisting of 142 amino acid residues, is an essential protein for cell viability, and the essential region is located in the C-terminal half between residues 61 and 139 [1].


  1. The Rpb6 subunit of fission yeast RNA polymerase II is a contact target of the transcription elongation factor TFIIS. Ishiguro, A., Nogi, Y., Hisatake, K., Muramatsu, M., Ishihama, A. Mol. Cell. Biol. (2000) [Pubmed]
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