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Gene Review:

pmp1 - dual-specificity MAP kinase phosphatase Pmp1

Schizosaccharomyces pombe 972h-

Wilkinson, M.G. et al., Shieh, J.C. et al.

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High impact information on pmp1

These genes include gpd1+, which is important for the response of cells to osmotic stress, the catalase gene lambda important for cells to combat oxidative stress, and pyp2+, which encodes a tyrosine-specific MAP kinase phosphatase [1].
We show that phosphorylation and activation of Sty1 under these conditions is not due to inactivation of the Pyp1 MAP kinase phosphatase [2].

References

The Atf1 transcription factor is a target for the Sty1 stress-activated MAP kinase pathway in fission yeast. Wilkinson, M.G., Samuels, M., Takeda, T., Toone, W.M., Shieh, J.C., Toda, T., Millar, J.B., Jones, N. Genes Dev. (1996) [Pubmed]
Evidence for a novel MAPKKK-independent pathway controlling the stress activated Sty1/Spc1 MAP kinase in fission yeast. Shieh, J.C., Martin, H., Millar, J.B. J. Cell. Sci. (1998) [Pubmed]

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