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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SDP1  -  Sdp1p

Saccharomyces cerevisiae S288c

Synonyms: Dual-specificity protein phosphatase SDP1, Stress-inducible MAPK phosphatase, YIL113W
 
 
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High impact information on SDP1

  • We show that SIN3 does not encode SDP1 and that SDP1 DNA-binding activity is modulated in vitro by two factors, an inhibitory factor, I-SDP1, and a stimulatory factor, S-SDP1 [1].
  • SDP1 DNA-binding activity was restored by treating a protein fraction containing SDP1 and I-SDP1 with the dissociating agent formamide [1].
  • The heat shock-induced phosphorylation level of Slt2 was elevated in an sdp1Delta strain compared with that of the wild type, and heat shock-activated phospho-Slt2 was dephosphorylated by recombinant Sdp1 in vitro [2].
  • We have attempted to clone two recessive extragenic suppressors of such ts mutants (sdp1 for mutation pol3-14 and sdp5-1 for mutation pol3-11) by transforming thermoresistant haploid strains pol3-14 sdp1 and pol3-11 sdp5-1 with wild-type genomic libraries in singlecopy or multicopy vectors [3].

References

  1. In vitro regulation of a SIN3-dependent DNA-binding activity by stimulatory and inhibitory factors. Wang, H., Stillman, D.J. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  2. Regulation of the Saccharomyces cerevisiae Slt2 kinase pathway by the stress-inducible Sdp1 dual specificity phosphatase. Hahn, J.S., Thiele, D.J. J. Biol. Chem. (2002) [Pubmed]
  3. Suppressors of thermosensitive mutations in the DNA polymerase delta gene of Saccharomyces cerevisiae. Giot, L., Simon, M., Dubois, C., Faye, G. Mol. Gen. Genet. (1995) [Pubmed]
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