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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

mcs2  -  TFIIH complex cyclin Mcs2

Schizosaccharomyces pombe 972h-

 
 
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High impact information on mcs2

  • Therefore, csk1 may encode a protein kinase physically associated with mcs2 or alternatively may function as an upstream activator of the mcs2-associated kinase [1].
  • This kinase activity is constant throughout the cell cycle. mcs2 does not appear to associate with the cdc2 protein kinase or an antigenically related kinase [1].
  • In contrast to the behavior of some, but not all cyclins, the mcs2 protein is constant in its abundance and localization throughout the cell cycle [1].
  • A kinase activity that co-precipitates with mcs2 can be detected when myelin basic protein (MBP) is provided as an exogenous substrate [1].
 

Biological context of mcs2

  • First, mcs2 cdc2w or mcs6 cdc2w double mutants display a cell cycle defect dependent on the specific wee allele of cdc2 [2].

References

  1. Characterization of the fission yeast mcs2 cyclin and its associated protein kinase activity. Molz, L., Beach, D. EMBO J. (1993) [Pubmed]
  2. cdc2 and the regulation of mitosis: six interacting mcs genes. Molz, L., Booher, R., Young, P., Beach, D. Genetics (1989) [Pubmed]
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