Disease relevance of Ccnh

• By quantitative real-time PCR, the mRNA expression of Rasa, Pi3kr1, Ccnh, and Il6st in carcinomas was, respectively, 22-, 20-, three- and threefold higher in carcinomas than in control mammary gland tissues (P<0.05, Student's t-test) [1].
• Molecular cloning of a cell cycle regulation gene cyclin H from ischemic rat brain: expression in neurons after global cerebral ischemia [2].

High impact information on Ccnh

• In addition, the proliferation index in mammary gland carcinomas as assessed by PCNA was found to correlate with the overexpression of Cyclin H by IHC analysis (P<0.05, Spearman Rank Order Correlation) [1].

Biological context of Ccnh

• These results suggest that cyclin H may have functions in neurons other than cell cycle regulation, including other known functions such as DNA repair [2].

Analytical, diagnostic and therapeutic context of Ccnh

• Northern blotting detected cyclin H mRNA in nonischemic and ischemic brains [2].
• In situ hybridization studies revealed that cyclin H message was found in hippocampal neurons in nonischemic brain [2].

References