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Gene Review

sep1  -  fork head transcription factor Sep1

Schizosaccharomyces pombe 972h-

 
 
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High impact information on sep1

  • The S. pombe sep1 gene encodes a nuclear protein that is required for periodic expression of the cdc15 gene [1].
  • Temporal changes in the transcription of sep1(+) correlate with the cell cycle progression showing maximal expression at the peak of cell plate index in synchronized cultures [2].
  • sep1(+), the Schizosaccharomyces pombe homologue of the forkhead/HNF-3 transcription factors, plays a role in the cell separation at the end of mitosis [2].
 

Analytical, diagnostic and therapeutic context of sep1

References

  1. The S. pombe sep1 gene encodes a nuclear protein that is required for periodic expression of the cdc15 gene. Zilahi, E., Salimova, E., Simanis, V., Sipiczki, M. FEBS Lett. (2000) [Pubmed]
  2. Deletion of the sep1(+) forkhead transcription factor homologue is not lethal but causes hyphal growth in Schizosaccharomyces pombe. Ribár, B., Grallert, A., Oláh, E., Szállási, Z. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
 
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