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Gene Review

cdc15  -  extended Fer/CIP4 (EFC) domain protein Cdc15

Schizosaccharomyces pombe 972h-

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High impact information on cdc15


Biological context of cdc15

  • If formation of the division septum is prevented by inactivation of either cdc14 or cdc15, p120cdc7 overproduction does not interfere with other events in the mitotic cell cycle [4].

Other interactions of cdc15

  • The S. pombe sep1 gene encodes a nuclear protein that is required for periodic expression of the cdc15 gene [5].
  • A more rapidly migrating byr4 protein was found in cells with mutations in cdc16, which undergo repeated septation, and in cdc15, which fail to form a medial F-actin ring in mitosis [6].
  • Mutations in the S. pombe early septation mutants cdc7, cdc11, cdc14 and cdc15 lead to the formation of elongated, multinucleate cells, as a result of S phase and mitosis continuing in the absence of cytokinesis [7].


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