High impact information on cdc15

• The abundance of cdc15 mRNA varies through the cell division cycle, peaking in early mitosis before septation [1].
• These data implicate cdc15p as a key element in mediating the cytoskeletal rearrangements required for cytokinesis [1].
• Overexpression of cdc15p in interphase cells induces abnormal membrane domain formation in an actin-independent manner [2].
• Organization of a sterol-rich membrane domain by cdc15p during cytokinesis in fission yeast [2].
• The disruption of these interactions in cdc15 null cells is likely to be the reason for their complete lack of CARs [3].

Biological context of cdc15

• If formation of the division septum is prevented by inactivation of either cdc14 or cdc15, p120cdc7 overproduction does not interfere with other events in the mitotic cell cycle [4].

Other interactions of cdc15

• The S. pombe sep1 gene encodes a nuclear protein that is required for periodic expression of the cdc15 gene [5].
• A more rapidly migrating byr4 protein was found in cells with mutations in cdc16, which undergo repeated septation, and in cdc15, which fail to form a medial F-actin ring in mitosis [6].
• Mutations in the S. pombe early septation mutants cdc7, cdc11, cdc14 and cdc15 lead to the formation of elongated, multinucleate cells, as a result of S phase and mitosis continuing in the absence of cytokinesis [7].

References