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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

mts4  -  19S proteasome regulatory subunit Mts4

Schizosaccharomyces pombe 972h-

 
 
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High impact information on mts4

  • We have isolated a fission yeast gene, mts4(+), by complementation of a temperature-sensitive mutation and show that it encodes subunit 2 (S2) of the 19 S regulatory complex of the 26 S protease. mts4(+) is an essential gene, and we show that loss of this subunit causes cells to arrest in metaphase, illustrating the importance of S2 for mitosis [1].
  • The Mts4 protein is 48% identical to S2 of the human 26 S protease, and the lethal phenotype of the null mts4 allele can be rescued by the human cDNA encoding S2 [1].

References

  1. Mts4, a non-ATPase subunit of the 26 S protease in fission yeast is essential for mitosis and interacts directly with the ATPase subunit Mts2. Wilkinson, C.R., Wallace, M., Seeger, M., Dubiel, W., Gordon, C. J. Biol. Chem. (1997) [Pubmed]
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