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Gene Review:

nup131 - nucleoporin Nup131

Schizosaccharomyces pombe 972h-

Novoa, I. et al., Thon, G. et al., Tange, Y. et al., Varadarajan, P. et al., Fischer, R. et al.

Thon, Hansen, Altes, Sidhu, Singh, Verhein-Hansen, Bonaduce, Klar,

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Disease relevance of SPBP35G2.06c

We report that the fission yeast nucleoporin Nup124p is required for the nuclear import of both, retrotransposon Tf1-Gag as well as the retroviral HIV-1 Vpr [1].

High impact information on SPBP35G2.06c

Two RBDs of the mammalian nucleoporin RanBP2 also rescued sbp1(-) yeast [2].
An evolutionarily conserved fission yeast protein, Ned1, implicated in normal nuclear morphology and chromosome stability, interacts with Dis3, Pim1/RCC1 and an essential nucleoporin [3].
Another physical interaction, between the nucleoporin Nup189 and Clr8, suggests that Clr8 might be involved in tethering heterochromatic regions to the nuclear envelope by association with the nuclear-pore complex [4].
Sequence analysis of a nuclear pore complex protein in a lower metazoan: nucleoporin p62 of the coelenterate Hydra vulgaris [5].

References

The functionally conserved nucleoporins Nup124p from fission yeast and the human Nup153 mediate nuclear import and activity of the Tf1 retrotransposon and HIV-1 Vpr. Varadarajan, P., Mahalingam, S., Liu, P., Ng, S.B., Gandotra, S., Dorairajoo, D.S., Balasundaram, D. Mol. Biol. Cell (2005) [Pubmed]
Isolated mammalian and Schizosaccharomyces pombe ran-binding domains rescue S. pombe sbp1 (RanBP1) genomic mutants. Novoa, I., Rush, M.G., D'Eustachio, P. Mol. Biol. Cell (1999) [Pubmed]
An evolutionarily conserved fission yeast protein, Ned1, implicated in normal nuclear morphology and chromosome stability, interacts with Dis3, Pim1/RCC1 and an essential nucleoporin. Tange, Y., Hirata, A., Niwa, O. J. Cell. Sci. (2002) [Pubmed]
The Clr7 and Clr8 directionality factors and the Pcu4 cullin mediate heterochromatin formation in the fission yeast Schizosaccharomyces pombe. Thon, G., Hansen, K.R., Altes, S.P., Sidhu, D., Singh, G., Verhein-Hansen, J., Bonaduce, M.J., Klar, A.J. Genetics (2005) [Pubmed]
Sequence analysis of a nuclear pore complex protein in a lower metazoan: nucleoporin p62 of the coelenterate Hydra vulgaris. Fischer, R., Cordes, V.C., Franke, W.W. Gene (1997) [Pubmed]

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