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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

cut8  -  tethering factor for nuclear proteasome Cut8

Schizosaccharomyces pombe 972h-

 
 
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High impact information on cut8

  • Further, cut8 null and cut8 K-all-R mutants are hypersensitive to DNA damage, probably due to the paucity of nuclear proteasome [1].
  • In cut8 mutants, chromosome mis-segregation and aberrant spindle dynamics occur, but cytokinesis takes place with normal timing, leading to the cut phenotype [2].
  • This is due to the fact that destruction of mitotic cyclin and Cut2 in the nucleus is dramatically delayed, though polyubiquitination of Cdc13 occurs in cut8 mutant [2].

References

  1. Regulation of nuclear proteasome by Rhp6/Ubc2 through ubiquitination and destruction of the sensor and anchor Cut8. Takeda, K., Yanagida, M. Cell (2005) [Pubmed]
  2. Cut8, essential for anaphase, controls localization of 26S proteasome, facilitating destruction of cyclin and Cut2. Tatebe, H., Yanagida, M. Curr. Biol. (2000) [Pubmed]
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