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Gene Review

cut8  -  tethering factor for nuclear proteasome Cut8

Schizosaccharomyces pombe 972h-

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High impact information on cut8

  • Further, cut8 null and cut8 K-all-R mutants are hypersensitive to DNA damage, probably due to the paucity of nuclear proteasome [1].
  • In cut8 mutants, chromosome mis-segregation and aberrant spindle dynamics occur, but cytokinesis takes place with normal timing, leading to the cut phenotype [2].
  • This is due to the fact that destruction of mitotic cyclin and Cut2 in the nucleus is dramatically delayed, though polyubiquitination of Cdc13 occurs in cut8 mutant [2].


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