The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

pas1  -  cyclin Pas1

Schizosaccharomyces pombe 972h-

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of pas1


High impact information on pas1


Biological context of pas1


Anatomical context of pas1

  • These results suggest a key regulatory role of the cdc2-cyclin complex in the initiation of mitotic spindle formation and also that mitotic microtubule function is required for cdc2 activation [10].
  • That they participate in the G2-M transition is supported by the fact that when synthetic cyclin messenger RNAs from clam and sea urchin are microinjected into the G2-arrested oocytes of Xenopus, they induce maturation [11].
  • Cytokinesis in eukaryotic cells requires the inactivation of mitotic cyclin-dependent kinase complexes [12].

Associations of pas1 with chemical compounds

  • Disruption of pas1+ causes defects in arginine and leucine uptake that are remarkably similar to Deltatsc1 and Deltatsc2, whereas Deltapas1Deltatsc1 and Deltapas1Deltatsc2 double mutants have more severe amino acid uptake defects [13].
  • The association of cyclin and p34cdc2 is not sufficient for activation of cdc2 kinase, however; dephosphorylation of key tyrosine and threonine residues of p34cdc2 is necessary to turn on its kinase activity [9].
  • We identified a truncated allele of dam1 as a multicopy suppressor of the sensitivity of cdc13-117 (cyclin B) and mal3-1 (EB-1) cells to thiabendazole, a microtubule poison [14].
  • However, little is known about how cyclic AMP interacts with the central cell cycle machinery, Cdc2, the cyclin-dependent kinase that induces mitosis [15].
  • Cyclin C and the cyclin C-dependent protein kinase are associated with the RNA polymerase II Mediator complex, which regulates initiation of transcription in response to signals from activators and repressors bound to upstream promoter elements [16].

Physical interactions of pas1


Regulatory relationships of pas1


Other interactions of pas1


Analytical, diagnostic and therapeutic context of pas1

  • The cellular distribution of the fission yeast mitotic cyclin B, p63cdc13, was investigated by a combination of indirect immunofluorescence light microscopy, immunogold electron microscopy, and nuclear isolation and fractionation [21].
  • Therefore, as observed by immunofluorescence in other systems, it seems that cyclin subunits target p34cdc2 to specific cellular sites and this is certainly important for its function [22].
  • It is becoming increasingly clear that the inactivation of the mitosis-promoting cyclin-dependent kinase, which marks the completion of the nuclear division cycle, is essential for actomyosin ring constriction and division septum assembly in both yeasts [23].


  1. 20S cyclosome complex formation and proteolytic activity inhibited by the cAMP/PKA pathway. Yamashita, Y.M., Nakaseko, Y., Samejima, I., Kumada, K., Yamada, H., Michaelson, D., Yanagida, M. Nature (1996) [Pubmed]
  2. Stable association of mitotic cyclin B/Cdc2 to replication origins prevents endoreduplication. Wuarin, J., Buck, V., Nurse, P., Millar, J.B. Cell (2002) [Pubmed]
  3. Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex. Hayles, J., Fisher, D., Woollard, A., Nurse, P. Cell (1994) [Pubmed]
  4. A fission yeast B-type cyclin functioning early in the cell cycle. Bueno, A., Richardson, H., Reed, S.I., Russell, P. Cell (1991) [Pubmed]
  5. Role of calcineurin and Mpk1 in regulating the onset of mitosis in budding yeast. Mizunuma, M., Hirata, D., Miyahara, K., Tsuchiya, E., Miyakawa, T. Nature (1998) [Pubmed]
  6. A pcl-like cyclin activates the Res2p-Cdc10p cell cycle "start" transcriptional factor complex in fission yeast. Tanaka, K., Okayama, H. Mol. Biol. Cell (2000) [Pubmed]
  7. Regulation of p34cdc2 protein kinase during mitosis. Moreno, S., Hayles, J., Nurse, P. Cell (1989) [Pubmed]
  8. Nim1 kinase promotes mitosis by inactivating Wee1 tyrosine kinase. Wu, L., Russell, P. Nature (1993) [Pubmed]
  9. Triggering of cyclin degradation in interphase extracts of amphibian eggs by cdc2 kinase. Félix, M.A., Labbé, J.C., Dorée, M., Hunt, T., Karsenti, E. Nature (1990) [Pubmed]
  10. Distinct nuclear and spindle pole body population of cyclin-cdc2 in fission yeast. Alfa, C.E., Ducommun, B., Beach, D., Hyams, J.S. Nature (1990) [Pubmed]
  11. Transcripts of one of two Drosophila cyclin genes become localized in pole cells during embryogenesis. Whitfield, W.G., González, C., Sánchez-Herrero, E., Glover, D.M. Nature (1989) [Pubmed]
  12. Study of cyclin proteolysis in anaphase-promoting complex (APC) mutant cells reveals the requirement for APC function in the final steps of the fission yeast septation initiation network. Chang, L., Morrell, J.L., Feoktistova, A., Gould, K.L. Mol. Cell. Biol. (2001) [Pubmed]
  13. Pas1, a G1 cyclin, regulates amino acid uptake and rescues a delay in G1 arrest in Tsc1 and Tsc2 mutants in Schizosaccharomyces pombe. van Slegtenhorst, M., Mustafa, A., Henske, E.P. Hum. Mol. Genet. (2005) [Pubmed]
  14. The DASH complex and Klp5/Klp6 kinesin coordinate bipolar chromosome attachment in fission yeast. Sanchez-Perez, I., Renwick, S.J., Crawley, K., Karig, I., Buck, V., Meadows, J.C., Franco-Sanchez, A., Fleig, U., Toda, T., Millar, J.B. EMBO J. (2005) [Pubmed]
  15. Cyclic AMP regulates cell size of Schizosaccharomyces pombe through Cdc25 mitotic inducer. Kishimoto, N., Yamashita, I. Yeast (2000) [Pubmed]
  16. Yeast genes GIS1-4: multicopy suppressors of the Gal- phenotype of snf1 mig1 srb8/10/11 cells. Balciunas, D., Ronne, H. Mol. Gen. Genet. (1999) [Pubmed]
  17. Fission yeast cdc25 is a cell-cycle regulated protein. Ducommun, B., Draetta, G., Young, P., Beach, D. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
  18. Cut8, essential for anaphase, controls localization of 26S proteasome, facilitating destruction of cyclin and Cut2. Tatebe, H., Yanagida, M. Curr. Biol. (2000) [Pubmed]
  19. Analysis of the Schizosaccharomyces pombe cyclin puc1: evidence for a role in cell cycle exit. Forsburg, S.L., Nurse, P. J. Cell. Sci. (1994) [Pubmed]
  20. Fission yeast cyclin: subcellular localisation and cell cycle regulation. Alfa, C.E., Booher, R., Beach, D., Hyams, J.S. J. Cell Sci. Suppl. (1989) [Pubmed]
  21. p63cdc13, a B-type cyclin, is associated with both the nucleolar and chromatin domains of the fission yeast nucleus. Gallagher, I.M., Alfa, C.E., Hyams, J.S. Mol. Biol. Cell (1993) [Pubmed]
  22. Association of cyclin-bound p34cdc2 with subcellular structures in xenopus eggs. Leiss, D., Félix, M.A., Karsenti, E. J. Cell. Sci. (1992) [Pubmed]
  23. Tying the knot: linking cytokinesis to the nuclear cycle. Balasubramanian, M.K., McCollum, D., Surana, U. J. Cell. Sci. (2000) [Pubmed]
WikiGenes - Universities