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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

pkl1  -  kinesin-like protein Pkl1

Schizosaccharomyces pombe 972h-

 
 
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High impact information on pkl1

  • When either or both deletions are combined with a dynein deletion, vegetative growth is normal, but sexual reproduction fails: klp2 Delta,dhc1-d1 in karyogamy, pkl1 Delta,dhc1-d1 in multiple phases of meiosis, and the triple deletion in both [1].
  • Previous research has found that a gamma-tubulin mutation in Schizosaccharomyces pombe is synthetically lethal with a deletion of the C-terminal motor domain kinesin-like protein gene pkl1, but the lethality of the double mutant prevents a phenotypic analysis of the synthetic interaction [2].
  • The movement is not dependent on cytoplasmic dynein dhc1, or kinesin-related proteins pkl1 and klp2 [3].

References

  1. pkl1(+)and klp2(+): Two kinesins of the Kar3 subfamily in fission yeast perform different functions in both mitosis and meiosis. Troxell, C.L., Sweezy, M.A., West, R.R., Reed, K.D., Carson, B.D., Pidoux, A.L., Cande, W.Z., McIntosh, J.R. Mol. Biol. Cell (2001) [Pubmed]
  2. Gamma-tubulin and the C-terminal motor domain kinesin-like protein, KLPA, function in the establishment of spindle bipolarity in Aspergillus nidulans. Prigozhina, N.L., Walker, R.A., Oakley, C.E., Oakley, B.R. Mol. Biol. Cell (2001) [Pubmed]
  3. The carboxy-terminus of Alp4 alters microtubule dynamics to induce oscillatory nuclear movement led by the spindle pole body in Schizosaccharomyces pombe. Masuda, H., Miyamoto, R., Haraguchi, T., Hiraoka, Y. Genes Cells (2006) [Pubmed]
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