High impact information on SPBC1685.15c

• Our investigations of kinesin-like proteins (klps) and morphological mutants in the fission yeast Schizosaccharomyces pombe have identified a kinesin-like gene, tea2(+), that is required for cells to generate proper polarized growth [1].
• Two kinesin-like Kin I family proteins in fission yeast regulate the establishment of metaphase and the onset of anaphase A [2].
• Two related kinesins, klp5+ and klp6+, foster microtubule disassembly and are required for meiosis in fission yeast [3].
• Previous research has found that a gamma-tubulin mutation in Schizosaccharomyces pombe is synthetically lethal with a deletion of the C-terminal motor domain kinesin-like protein gene pkl1, but the lethality of the double mutant prevents a phenotypic analysis of the synthetic interaction [4].
• Kinesins klp5(+) and klp6(+) are required for normal chromosome movement in mitosis [5].

Biological context of SPBC1685.15c

• Here we demonstrate that two related fission yeast kinesins, klp5(+) and klp6(+), are required for normal chromosome segregation in mitosis [5].
• We identified 11 kinesin-like proteins in the genome of the filamentous fungus Aspergillus nidulans [6].

Other interactions of SPBC1685.15c

• We showed that klp5 or klp6 inactivation in combination with the scd1 deletion (scd1delta) created a synthetic temperature-dependent growth defect [7].

References