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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

cut23  -  anaphase-promoting complex subunit Apc8

Schizosaccharomyces pombe 972h-

 
 
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High impact information on SPAC6F12.14

  • A new cut23 mutation, which specifically disrupts the interaction with Plo1, results in a metaphase arrest [1].
  • Surprisingly, the phenotypes of cut9 and cut23 in the presence of pCUT1 or pCUT2 were not the mitotic arrest, and they were strikingly different depending on pCUT1 or pCUT2 [2].
  • The gene products of cut20+ and cut23+ were thus identified [3].

References

  1. Polo boxes and Cut23 (Apc8) mediate an interaction between polo kinase and the anaphase-promoting complex for fission yeast mitosis. May, K.M., Reynolds, N., Cullen, C.F., Yanagida, M., Ohkura, H. J. Cell Biol. (2002) [Pubmed]
  2. A brute force postgenome approach to identify temperature-sensitive mutations that negatively interact with separase and securin plasmids. Matsumura, T., Yuasa, T., Hayashi, T., Obara, T., Kimata, Y., Yanagida, M. Genes Cells (2003) [Pubmed]
  3. Fission yeast APC/cyclosome subunits, Cut20/Apc4 and Cut23/Apc8, in regulating metaphase-anaphase progression and cellular stress responses. Yamashita, Y.M., Nakaseko, Y., Kumada, K., Nakagawa, T., Yanagida, M. Genes Cells (1999) [Pubmed]
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