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Gene Review:

CDC23 - cell division cycle 23

Homo sapiens

Synonyms: ANAPC8, APC8, Anaphase-promoting complex subunit 8, CUT23, Cell division cycle protein 23 homolog, ...

Zhao, N. et al., Locovei, A.M. et al.

Locovei, Spiga, Tanaka, Murakami, D'Urso,

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Disease relevance of CDC23

Thus, CDC23 is unlikely to be involved in the pathogenesis of myeloid leukemias characterized by abnormalities of chromosome 5 [1].

High impact information on CDC23

The human CDC23 gene contains 16 exons and spans approximately 31 kb [1].
We have isolated the human CDC23 cDNA containing the full-length predicted open reading frame [1].
Human CDC23: cDNA cloning, mapping to 5q31, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias [1].
Here we show that Abp1 interacts with the DNA replication protein Cdc23 (MCM10) in a two-hybrid assay, and that the Deltaabp1 mutant displays a synthetic phenotype with a cdc23 temperature-sensitive mutant [2].
The CENP-B homolog, Abp1, interacts with the initiation protein Cdc23 (MCM10) and is required for efficient DNA replication in fission yeast [2].

References

Human CDC23: cDNA cloning, mapping to 5q31, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias. Zhao, N., Lai, F., Fernald, A.A., Eisenbart, J.D., Espinosa, R., Wang, P.W., Le Beau, M.M. Genomics (1998) [Pubmed]
The CENP-B homolog, Abp1, interacts with the initiation protein Cdc23 (MCM10) and is required for efficient DNA replication in fission yeast. Locovei, A.M., Spiga, M.G., Tanaka, K., Murakami, Y., D'Urso, G. Cell division (2006) [Pubmed]

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AgaP_AGAP009880	Anopheles gambiae str. PEST
APC8	Arabidopsis thaliana
AGOS_ABR206W	Ashbya gossypii ATCC 10895
CDC23	Bos taurus
CDC23	Canis lupus familiaris
cdc23	Danio rerio
Cdc23	Drosophila melanogaster
CG31687	Drosophila melanogaster
CDC23	Gallus gallus
KLLA0A05258g	Kluyveromyces lactis NRRL Y-1140
CDC23	Macaca mulatta
MGG_08648	Magnaporthe oryzae 70-15
Cdc23	Mus musculus
NCU01174	Neurospora crassa OR74A
Os02g0656300	Oryza sativa Japonica Group
CDC23	Pan troglodytes
Cdc23	Rattus norvegicus
CDC23	Saccharomyces cerevisiae S288c
cut23	Schizosaccharomyces pombe 972h-
cdc23	Xenopus (Silurana) tropicalis

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