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Gene Review:

cut9 - anaphase-promoting complex subunit Cut9

Schizosaccharomyces pombe 972h-

Samejima, I. et al., Yamada, H. et al., Matsumura, T. et al.

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High impact information on cut9

The three genes, namely, nuc2+, scn1+, and scn2+, genetically interact with cut9+ [1].
Bypassing anaphase by fission yeast cut9 mutation: requirement of cut9+ to initiate anaphase [1].
In contrast, PP1 (Dis2) phosphatase mutation shows the reverse effect on the phenotype of cut9 [2].
Furthermore, deletion of protein kinase PKA (Pkal) suppresses the phenotype of the cut9 mutation and reduces phosphorylation of Cut9 [2].
Surprisingly, the phenotypes of cut9 and cut23 in the presence of pCUT1 or pCUT2 were not the mitotic arrest, and they were strikingly different depending on pCUT1 or pCUT2 [3].

Biological context of cut9

The nuc2+ and cut9+ genes share an essential function to initiate anaphase [1].

References

Bypassing anaphase by fission yeast cut9 mutation: requirement of cut9+ to initiate anaphase. Samejima, I., Yanagida, M. J. Cell Biol. (1994) [Pubmed]
Distinct subunit functions and cell cycle regulated phosphorylation of 20S APC/cyclosome required for anaphase in fission yeast. Yamada, H., Kumada, K., Yanagida, M. J. Cell. Sci. (1997) [Pubmed]
A brute force postgenome approach to identify temperature-sensitive mutations that negatively interact with separase and securin plasmids. Matsumura, T., Yuasa, T., Hayashi, T., Obara, T., Kimata, Y., Yanagida, M. Genes Cells (2003) [Pubmed]

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