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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ND4  -  NADH dehydrogenase subunit 4

Caenorhabditis elegans

 
 
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High impact information on ND4

  • On the other hand, the high substitution rate in genes such as ND4 should make them excellent for population genetics studies, identifying cryptic species, and resolving relationships among closely related congeners when other markers show insufficient variation [1].
  • The genetic diversity of the mtDNA ND4 gene in 11 Teladorsagia circumcincta populations from France and Morocco was assessed by sequencing [2].
  • Molecular differentiation and phylogeny of entomopathogenic nematodes (rhabditida: heterorhabditidae) based on ND4 gene sequences of Mitochondrial DNA [3].
 

Biological context of ND4

  • Our molecular phylogeny of Heterorhabditis species support an existing taxonomy that is based largely on morphology and the sequence divergence of the ND4 gene permits species identification [3].
 

Analytical, diagnostic and therapeutic context of ND4

  • We determined partial ND4 gene sequences of mitochondrial DNA from 15 heterorhabditid nematode isolates, representing 5 species collected from different regions of the world, by using polymerase chain reaction (PCR) and direct-sequencing of PCR products [3].

References

  1. Substitution bias, rapid saturation, and the use of mtDNA for nematode systematics. Blouin, M.S., Yowell, C.A., Courtney, C.H., Dame, J.B. Mol. Biol. Evol. (1998) [Pubmed]
  2. Mitochondrial DNA variation in benzimidazole-resistant and -susceptible populations of the small ruminant parasite Teladorsagia circumcincta. Leignel, V., Humbert, J.F. J. Hered. (2001) [Pubmed]
  3. Molecular differentiation and phylogeny of entomopathogenic nematodes (rhabditida: heterorhabditidae) based on ND4 gene sequences of Mitochondrial DNA. Liu, J., Berry, R.E., Blouin, M.S. J. Parasitol. (1999) [Pubmed]
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