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Gene Review:

Itgb4 - integrin, beta 4

Rattus norvegicus

Synonyms: GP150, Integrin beta-4

Hammarberg, H. et al., Litjens, S.H. et al., Tsuruta, D. et al.

Hammarberg, Wallquist, Piehl, Risling, Cullheim,

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High impact information on Itgb4

Crucial role of the specificity-determining loop of the integrin beta4 subunit in the binding of cells to laminin-5 and outside-in signal transduction [1].
Plectin is a major component of the cytoskeleton and links the intermediate filament system to hemidesmosomes by binding to the integrin beta4 subunit [2].

Analytical, diagnostic and therapeutic context of Itgb4

We have here, by use of in situ hybridization histochemistry, examined the normal postnatal development of the expression in motoneurons of these mRNAs and integrin beta 4 mRNA, all of which have been associated with laminin-2 [3].

References

Crucial role of the specificity-determining loop of the integrin beta4 subunit in the binding of cells to laminin-5 and outside-in signal transduction. Tsuruta, D., Hopkinson, S.B., Lane, K.D., Werner, M.E., Cryns, V.L., Jones, J.C. J. Biol. Chem. (2003) [Pubmed]
Specificity of binding of the plectin actin-binding domain to beta4 integrin. Litjens, S.H., Koster, J., Kuikman, I., van Wilpe, S., de Pereda, J.M., Sonnenberg, A. Mol. Biol. Cell (2003) [Pubmed]
Regulation of laminin-associated integrin subunit mRNAs in rat spinal motoneurons during postnatal development and after axonal injury. Hammarberg, H., Wallquist, W., Piehl, F., Risling, M., Cullheim, S. J. Comp. Neurol. (2000) [Pubmed]

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