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Gene Review

Itgb4  -  integrin, beta 4

Rattus norvegicus

Synonyms: GP150, Integrin beta-4
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High impact information on Itgb4


Analytical, diagnostic and therapeutic context of Itgb4

  • We have here, by use of in situ hybridization histochemistry, examined the normal postnatal development of the expression in motoneurons of these mRNAs and integrin beta 4 mRNA, all of which have been associated with laminin-2 [3].


  1. Crucial role of the specificity-determining loop of the integrin beta4 subunit in the binding of cells to laminin-5 and outside-in signal transduction. Tsuruta, D., Hopkinson, S.B., Lane, K.D., Werner, M.E., Cryns, V.L., Jones, J.C. J. Biol. Chem. (2003) [Pubmed]
  2. Specificity of binding of the plectin actin-binding domain to beta4 integrin. Litjens, S.H., Koster, J., Kuikman, I., van Wilpe, S., de Pereda, J.M., Sonnenberg, A. Mol. Biol. Cell (2003) [Pubmed]
  3. Regulation of laminin-associated integrin subunit mRNAs in rat spinal motoneurons during postnatal development and after axonal injury. Hammarberg, H., Wallquist, W., Piehl, F., Risling, M., Cullheim, S. J. Comp. Neurol. (2000) [Pubmed]
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