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Gene Review

Itgb4  -  integrin beta 4

Mus musculus

Synonyms: AA407042, C230078O20, CD104, Integrin beta-4
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Disease relevance of Itgb4


High impact information on Itgb4


Biological context of Itgb4


Anatomical context of Itgb4


Associations of Itgb4 with chemical compounds


Other interactions of Itgb4

  • Furthermore, the addition of Matrigel to the hepatoblast culture upregulated the expression of cytokeratin 7 and 19, integrin beta4, and HNF1beta, which are known to be expressed in cholangiocytes [16].

Analytical, diagnostic and therapeutic context of Itgb4


  1. Copy number aberrations in mouse breast tumors reveal loci and genes important in tumorigenic receptor tyrosine kinase signaling. Hodgson, J.G., Malek, T., Bornstein, S., Hariono, S., Ginzinger, D.G., Muller, W.J., Gray, J.W. Cancer Res. (2005) [Pubmed]
  2. Integrin beta 4 mutations associated with junctional epidermolysis bullosa with pyloric atresia. Vidal, F., Aberdam, D., Miquel, C., Christiano, A.M., Pulkkinen, L., Uitto, J., Ortonne, J.P., Meneguzzi, G. Nat. Genet. (1995) [Pubmed]
  3. Splicing modulation of integrin beta4 pre-mRNA carrying a branch point mutation underlies epidermolysis bullosa with pyloric atresia undergoing spontaneous amelioration with ageing. Chavanas, S., Gache, Y., Vailly, J., Kanitakis, J., Pulkkinen, L., Uitto, J., Ortonne, J., Meneguzzi, G. Hum. Mol. Genet. (1999) [Pubmed]
  4. Differential gene expression profiles of scirrhous gastric cancer cells with high metastatic potential to peritoneum or lymph nodes. Hippo, Y., Yashiro, M., Ishii, M., Taniguchi, H., Tsutsumi, S., Hirakawa, K., Kodama, T., Aburatani, H. Cancer Res. (2001) [Pubmed]
  5. Functional suppression of integrin beta 4-mediated adhesion caused by in vivo sequential selection for cancer cell intravasation. Ota, T., Maeda, M., Tanino, M., Tatsuka, M. Anticancer Res. (2001) [Pubmed]
  6. Epithelial detachment due to absence of hemidesmosomes in integrin beta 4 null mice. van der Neut, R., Krimpenfort, P., Calafat, J., Niessen, C.M., Sonnenberg, A. Nat. Genet. (1996) [Pubmed]
  7. Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in mice. Georges-Labouesse, E., Messaddeq, N., Yehia, G., Cadalbert, L., Dierich, A., Le Meur, M. Nat. Genet. (1996) [Pubmed]
  8. Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain. Murgia, C., Blaikie, P., Kim, N., Dans, M., Petrie, H.T., Giancotti, F.G. EMBO J. (1998) [Pubmed]
  9. Targeted deletion of the integrin beta4 signaling domain suppresses laminin-5-dependent nuclear entry of mitogen-activated protein kinases and NF-kappaB, causing defects in epidermal growth and migration. Nikolopoulos, S.N., Blaikie, P., Yoshioka, T., Guo, W., Puri, C., Tacchetti, C., Giancotti, F.G. Mol. Cell. Biol. (2005) [Pubmed]
  10. Partial rescue of epithelial phenotype in integrin beta4 null mice by a keratin-5 promoter driven human integrin beta4 transgene. van der Neut, R., Cachaço, A.S., Thorsteinsdóttir, S., Janssen, H., Prins, D., Bulthuis, J., van der Valk, M., Calafat, J., Sonnenberg, A. J. Cell. Sci. (1999) [Pubmed]
  11. Inhibition of PC-PLC Blocked the Survival of Mouse Neural Cells by Up-Regulating the Expression of Integrin beta4 and Rb. Lv, X., Wang, N., Su, L., Zhang, S., Miao, J. Dev. Neurosci. (2006) [Pubmed]
  12. Integrin alpha 6 is a differentiation antigen of human granulosa cells. Honda, T., Fujiwara, H., Ueda, M., Maeda, M., Mori, T. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  13. The beta 4 integrin subunit is expressed in mouse fibroblasts and modulated by transforming growth factor-beta 1. Scardigli, R., Soddu, S., Falcioni, R., Crescenzi, M., Cimino, L., Sacchi, A. Exp. Cell Res. (1996) [Pubmed]
  14. The effect of gelatin-chondroitin sulfate-hyaluronic acid skin substitute on wound healing in SCID mice. Wang, T.W., Sun, J.S., Wu, H.C., Tsuang, Y.H., Wang, W.H., Lin, F.H. Biomaterials (2006) [Pubmed]
  15. Keratinocytes display normal proliferation, survival and differentiation in conditional beta4-integrin knockout mice. Raymond, K., Kreft, M., Janssen, H., Calafat, J., Sonnenberg, A. J. Cell. Sci. (2005) [Pubmed]
  16. Notch signaling controls hepatoblast differentiation by altering the expression of liver-enriched transcription factors. Tanimizu, N., Miyajima, A. J. Cell. Sci. (2004) [Pubmed]
  17. Integrin alpha 6B beta 1 is involved in kidney tubulogenesis in vitro. Falk, M., Salmivirta, K., Durbeej, M., Larsson, E., Ekblom, M., Vestweber, D., Ekblom, P. J. Cell. Sci. (1996) [Pubmed]
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