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Gene Review

SIN3A  -  SIN3 transcription regulator family member A

Homo sapiens

Synonyms: DKFZP434K2235, Histone deacetylase complex subunit Sin3a, KIAA0700, Paired amphipathic helix protein Sin3a, Transcriptional corepressor Sin3a
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High impact information on SIN3A

  • MeCP2 selectively binds CpG dinucleotides in the mammalian genome and mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A (refs 12,13) [1].
  • We suggest that the ICR positioned close to the enhancers in an episomal context might function as a transcriptional silencer by virtue of interaction of CTCF with its modifiers such as SIN3A and histone deacetylases [2].
  • Two distinct regions of SIN3A, the PAH3 domain and the extreme C-terminal region, bind independently to this zinc-finger cluster [3].

Physical interactions of SIN3A

  • Furthermore, the ability of regions of CTCF to retain deacetylase activity correlates with the ability to bind to SIN3A and to repress gene activity [3].


  1. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Amir, R.E., Van den Veyver, I.B., Wan, M., Tran, C.Q., Francke, U., Zoghbi, H.Y. Nat. Genet. (1999) [Pubmed]
  2. Igf2/H19 imprinting control region (ICR): an insulator or a position-dependent silencer? Banerjee, S., Smallwood, A., Lamond, S., Campbell, S., Nargund, G. ScientificWorldJournal (2001) [Pubmed]
  3. Transcriptional repression by the insulator protein CTCF involves histone deacetylases. Lutz, M., Burke, L.J., Barreto, G., Goeman, F., Greb, H., Arnold, R., Schultheiss, H., Brehm, A., Kouzarides, T., Lobanenkov, V., Renkawitz, R. Nucleic Acids Res. (2000) [Pubmed]
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