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Gene Review

EGFL6  -  EGF-like-domain, multiple 6

Homo sapiens

Synonyms: EGF-like protein 6, Epidermal growth factor-like protein 6, MAEG, MAM and EGF domains-containing gene protein, PP648, ...
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High impact information on EGFL6

  • Studies on the wild type and mutants helped to assign the fast picosecond lifetime component to the W80 residue, which exhibits fast fluorescence energy transfer to the [Fe(4)S(4)](3+) cluster of the protein [1].
  • Sequence analysis indicates that MAEG encodes a secreted protein characterized by the presence of five EGF repeats, three of which display a Ca(2+)-binding consensus sequence [2].
  • Cloning of a novel epidermal growth factor repeat containing gene EGFL6: expressed in tumor and fetal tissues [3].
  • However, W80 lying in close proximity of the calcium binding sites is expected to have considerable PC affinity but negligible calcium induced effect on PC binding [4].


  1. Steady-state and time-resolved fluorescence studies on wild type and mutant chromatium vinosum high potential iron proteins: holo- and apo-forms. Sau, A.K., Chen, C.A., Cowan, J.A., Mazumdar, S., Mitra, S. Biophys. J. (2001) [Pubmed]
  2. Identification of a new EGF-repeat-containing gene from human Xp22: a candidate for developmental disorders. Buchner, G., Orfanelli, U., Quaderi, N., Bassi, M.T., Andolfi, G., Ballabio, A., Franco, B. Genomics (2000) [Pubmed]
  3. Cloning of a novel epidermal growth factor repeat containing gene EGFL6: expressed in tumor and fetal tissues. Yeung, G., Mulero, J.J., Berntsen, R.P., Loeb, D.B., Drmanac, R., Ford, J.E. Genomics (1999) [Pubmed]
  4. Characterization of calcium and magnesium binding domains of human 5-lipoxygenase. Bindu, P.H., Sastry, G.M., Sastry, G.N. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
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