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Gene Review

LSM14A  -  LSM14A, SCD6 homolog A (S. cerevisiae)

Homo sapiens

Synonyms: AlphaSNBP, C19orf13, DKFZP434D1335, FAM61A, Protein FAM61A, ...
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High impact information on LSM14A

  • RAP55 localized to cytoplasmic foci in Xenopus oocytes and the processing bodies (P-bodies) in cultured human cells: in the latter cells, RAP55 is an essential constituent of the P-bodies [1].
  • After cells were subjected to arsenite-induced stress, RAP55 was detected in TIA-containing stress granules [2].
  • The second RGG domain was necessary and sufficient for stress granule localization. siRNA-mediated knock-down of RAP55 resulted in loss of P-bodies, suggesting that RAP55 acts prior to the 5'-decapping step in mRNA degradation [2].

Anatomical context of LSM14A


  1. RAP55, a Cytoplasmic mRNP Component, Represses Translation in Xenopus Oocytes. Tanaka, K.J., Ogawa, K., Takagi, M., Imamoto, N., Matsumoto, K., Tsujimoto, M. J. Biol. Chem. (2006) [Pubmed]
  2. RNA-associated protein 55 (RAP55) localizes to mRNA processing bodies and stress granules. Yang, W.H., Yu, J.H., Gulick, T., Bloch, K.D., Bloch, D.B. RNA (2006) [Pubmed]
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