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Chemical Compound Review

Trisonex     arsenic(+3) cation; oxygen(-2) anion

Synonyms: CCRIS 5455, UN1561, FT-0622486, UN 1561, AI3-01163, ...
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Disease relevance of UN1561


Psychiatry related information on UN1561


High impact information on UN1561


Chemical compound and disease context of UN1561


Biological context of UN1561


Anatomical context of UN1561


Associations of UN1561 with other chemical compounds

  • In acute promyelocytic leukemia, PML/retinoic acid receptor (RAR) alpha expression disrupts NBs, but therapies such as retinoic acid or arsenic trioxide (As2O3) restore them [28].
  • A variant selected for resistance to antimony potassium tartrate was cross-resistant to DDP and arsenite [29].
  • MRP1 can even confer resistance to arsenite and MRP2 to cisplatin, again probably by transporting these compounds in complexes with GSH [30].
  • Based on these structural features, we propose that the metal-binding site is involved directly in the process of vectorial translocation of arsenite or antimonite across the membrane [31].
  • In vitro analysis, however, reveals a differential effect of stress on splicing: nuclear extracts from cells exposed to a severe heat shock are incapable of splicing an exogenously supplied substrate while splicing is not perturbed in extracts treated with sodium arsenite, the amino acid analog canavinine or ethanol [32].

Gene context of UN1561

  • Exclusion of TTP from arsenite-induced SGs is a consequence of MAPKAP kinase-2 (MK2)-induced phosphorylation at serines 52 and 178, which promotes the assembly of TTP:14-3-3 complexes [21].
  • Here, we show that G3BP, a phosphorylation-dependent endoribonuclease that interacts with RasGAP, is recruited to SGs in cells exposed to arsenite [33].
  • Ten mutations were located in arsB, encoding the arsenite membrane pump, resulting in a fourfold to sixfold increase in arsenite resistance [34].
  • We also show that MRP increases the export of glutathione from the cell and this increased export is further elevated in the presence of arsenite [35].
  • Disruption of either the ACR3 or YCF1 gene results in sensitivity to arsenite and disruption of both genes produces additive hypersensitivity [27].

Analytical, diagnostic and therapeutic context of UN1561


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  2. Rhabdomyolysis in fatal arsenic trioxide poisoning. Sanz, P., Corbella, J., Nogué, S., Munné, P., Rodriguez-Pazos, M. JAMA (1989) [Pubmed]
  3. 150-kD oxygen-regulated protein is expressed in human atherosclerotic plaques and allows mononuclear phagocytes to withstand cellular stress on exposure to hypoxia and modified low density lipoprotein. Tsukamoto, Y., Kuwabara, K., Hirota, S., Ikeda, J., Stern, D., Yanagi, H., Matsumoto, M., Ogawa, S., Kitamura, Y. J. Clin. Invest. (1996) [Pubmed]
  4. Prolongation of the QT interval and ventricular tachycardia in patients treated with arsenic trioxide for acute promyelocytic leukemia. Ohnishi, K., Yoshida, H., Shigeno, K., Nakamura, S., Fujisawa, S., Naito, K., Shinjo, K., Fujita, Y., Matsui, H., Takeshita, A., Sugiyama, S., Satoh, H., Terada, H., Ohno, R. Ann. Intern. Med. (2000) [Pubmed]
  5. The environmental toxin arsenite induces tau hyperphosphorylation. Giasson, B.I., Sampathu, D.M., Wilson, C.A., Vogelsberg-Ragaglia, V., Mushynski, W.E., Lee, V.M. Biochemistry (2002) [Pubmed]
  6. Cell cycle inhibition by sodium arsenite in primary embryonic rat midbrain neuroepithelial cells. Sidhu, J.S., Ponce, R.A., Vredevoogd, M.A., Yu, X., Gribble, E., Hong, S.W., Schneider, E., Faustman, E.M. Toxicol. Sci. (2006) [Pubmed]
  7. In vivo genotoxic effect of arsenic trioxide in mice using comet assay.  Saleha Banu, B., Danadevi, K., Jamil, K., Ahuja, Y.R., Visweswara Rao, K., Ishaq, M. Toxicology (2001) [Pubmed]
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  9. Treatment of acute promyelocytic leukemia with arsenic trioxide. Tamm, I., Paternostro, G., Zapata, J.M. N. Engl. J. Med. (1999) [Pubmed]
  10. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Rouse, J., Cohen, P., Trigon, S., Morange, M., Alonso-Llamazares, A., Zamanillo, D., Hunt, T., Nebreda, A.R. Cell (1994) [Pubmed]
  11. Induction of gene amplification by arsenic. Lee, T.C., Tanaka, N., Lamb, P.W., Gilmer, T.M., Barrett, J.C. Science (1988) [Pubmed]
  12. An Arsenite-Inducible 19S Regulatory Particle-Associated Protein Adapts Proteasomes to Proteotoxicity. Stanhill, A., Haynes, C.M., Zhang, Y., Min, G., Steele, M.C., Kalinina, J., Martinez, E., Pickart, C.M., Kong, X.P., Ron, D. Mol. Cell (2006) [Pubmed]
  13. In vivo activation of cAMP signaling induces growth arrest and differentiation in acute promyelocytic leukemia. Guillemin, M.C., Raffoux, E., Vitoux, D., Kogan, S., Soilihi, H., Lallemand-Breitenbach, V., Zhu, J., Janin, A., Daniel, M.T., Gourmel, B., Degos, L., Dombret, H., Lanotte, M., De Thé, H. J. Exp. Med. (2002) [Pubmed]
  14. Engineering tolerance and hyperaccumulation of arsenic in plants by combining arsenate reductase and gamma-glutamylcysteine synthetase expression. Dhankher, O.P., Li, Y., Rosen, B.P., Shi, J., Salt, D., Senecoff, J.F., Sashti, N.A., Meagher, R.B. Nat. Biotechnol. (2002) [Pubmed]
  15. Inhibition of apoptosis in acute promyelocytic leukemia cells leads to increases in levels of oxidized protein and LMP2 immunoproteasome. Khan, M.A., Oubrahim, H., Stadtman, E.R. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  16. Use of all-trans retinoic acid plus arsenic trioxide as an alternative to chemotherapy in untreated acute promyelocytic leukemia. Estey, E., Garcia-Manero, G., Ferrajoli, A., Faderl, S., Verstovsek, S., Jones, D., Kantarjian, H. Blood (2006) [Pubmed]
  17. Pharmacologic inhibitors of PI3K/Akt potentiate the apoptotic action of the antileukemic drug arsenic trioxide via glutathione depletion and increased peroxide accumulation in myeloid leukemia cells. Ramos, A.M., Fernández, C., Amrán, D., Sancho, P., de Blas, E., Aller, P. Blood (2005) [Pubmed]
  18. Distinct stimulus-specific histone modifications at hsp70 chromatin targeted by the transcription factor heat shock factor-1. Thomson, S., Hollis, A., Hazzalin, C.A., Mahadevan, L.C. Mol. Cell (2004) [Pubmed]
  19. Apoptosis and growth inhibition in malignant lymphocytes after treatment with arsenic trioxide at clinically achievable concentrations. Zhu, X.H., Shen, Y.L., Jing, Y.K., Cai, X., Jia, P.M., Huang, Y., Tang, W., Shi, G.Y., Sun, Y.P., Dai, J., Wang, Z.Y., Chen, S.J., Zhang, T.D., Waxman, S., Chen, Z., Chen, G.Q. J. Natl. Cancer Inst. (1999) [Pubmed]
  20. Changes in the methylation pattern of core histones during heat-shock in Drosophila cells. Camato, R., Tanguay, R.M. EMBO J. (1982) [Pubmed]
  21. MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay. Stoecklin, G., Stubbs, T., Kedersha, N., Wax, S., Rigby, W.F., Blackwell, T.K., Anderson, P. EMBO J. (2004) [Pubmed]
  22. Regulation of heat-shock genes: a DNA sequence upstream of Drosophila hsp70 genes is essential for their induction in monkey cells. Mirault, M.E., Southgate, R., Delwart, E. EMBO J. (1982) [Pubmed]
  23. Inorganic arsenite-induced malignant transformation of human prostate epithelial cells. Achanzar, W.E., Brambila, E.M., Diwan, B.A., Webber, M.M., Waalkes, M.P. J. Natl. Cancer Inst. (2002) [Pubmed]
  24. Spontaneous high expression of heat-shock proteins in mouse embryonal carcinoma cells and ectoderm from day 8 mouse embryo. Bensaude, O., Morange, M. EMBO J. (1983) [Pubmed]
  25. Arsenate induces stress proteins in cultured rat myoblasts. Kim, Y.J., Shuman, J., Sette, M., Przybyla, A. J. Cell Biol. (1983) [Pubmed]
  26. An arsenic metallochaperone for an arsenic detoxification pump. Lin, Y.F., Walmsley, A.R., Rosen, B.P. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  27. Pathways of As(III) detoxification in Saccharomyces cerevisiae. Ghosh, M., Shen, J., Rosen, B.P. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  28. Role of promyelocytic leukemia (PML) sumolation in nuclear body formation, 11S proteasome recruitment, and As2O3-induced PML or PML/retinoic acid receptor alpha degradation. Lallemand-Breitenbach, V., Zhu, J., Puvion, F., Koken, M., Honoré, N., Doubeikovsky, A., Duprez, E., Pandolfi, P.P., Puvion, E., Freemont, P., de Thé, H. J. Exp. Med. (2001) [Pubmed]
  29. Cross-resistance between cisplatin, antimony potassium tartrate, and arsenite in human tumor cells. Naredi, P., Heath, D.D., Enns, R.E., Howell, S.B. J. Clin. Invest. (1995) [Pubmed]
  30. A family of drug transporters: the multidrug resistance-associated proteins. Borst, P., Evers, R., Kool, M., Wijnholds, J. J. Natl. Cancer Inst. (2000) [Pubmed]
  31. Structure of the ArsA ATPase: the catalytic subunit of a heavy metal resistance pump. Zhou, T., Radaev, S., Rosen, B.P., Gatti, D.L. EMBO J. (2000) [Pubmed]
  32. Heat shock but not other stress inducers leads to the disruption of a sub-set of snRNPs and inhibition of in vitro splicing in HeLa cells. Bond, U. EMBO J. (1988) [Pubmed]
  33. The RasGAP-associated endoribonuclease G3BP assembles stress granules. Tourrière, H., Chebli, K., Zekri, L., Courselaud, B., Blanchard, J.M., Bertrand, E., Tazi, J. J. Cell Biol. (2003) [Pubmed]
  34. Molecular evolution of an arsenate detoxification pathway by DNA shuffling. Crameri, A., Dawes, G., Rodriguez, E., Silver, S., Stemmer, W.P. Nat. Biotechnol. (1997) [Pubmed]
  35. Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein. Zaman, G.J., Lankelma, J., van Tellingen, O., Beijnen, J., Dekker, H., Paulusma, C., Oude Elferink, R.P., Baas, F., Borst, P. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  36. Vitamin C protects HL60 and U266 cells from arsenic toxicity. Karasavvas, N., Cárcamo, J.M., Stratis, G., Golde, D.W. Blood (2005) [Pubmed]
  37. Acute promyelocytic leukemia: evolving therapeutic strategies. Tallman, M.S., Nabhan, C., Feusner, J.H., Rowe, J.M. Blood (2002) [Pubmed]
  38. 70-Kilodalton heat shock polypeptides from rainbow trout: characterization of cDNA sequences. Kothary, R.K., Jones, D., Candido, E.P. Mol. Cell. Biol. (1984) [Pubmed]
  39. Studies on treatment of acute promyelocytic leukemia with arsenic trioxide: remission induction, follow-up, and molecular monitoring in 11 newly diagnosed and 47 relapsed acute promyelocytic leukemia patients. Niu, C., Yan, H., Yu, T., Sun, H.P., Liu, J.X., Li, X.S., Wu, W., Zhang, F.Q., Chen, Y., Zhou, L., Li, J.M., Zeng, X.Y., Yang, R.R., Yuan, M.M., Ren, M.Y., Gu, F.Y., Cao, Q., Gu, B.W., Su, X.Y., Chen, G.Q., Xiong, S.M., Zhang, T.D., Waxman, S., Wang, Z.Y., Chen, Z., Hu, J., Shen, Z.X., Chen, S.J. Blood (1999) [Pubmed]
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