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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

WIPI2  -  WD repeat domain, phosphoinositide...

Homo sapiens

Synonyms: ATG18B, Atg21, CGI-50, DKFZP434J154, DKFZp686P02188, ...
 
 
 
 
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High impact information on WIPI2

  • Atg18 and Atg21 are homologous S. cerevisiae autophagy proteins [1].
  • Atg18 is essential for biogenesis of Cvt vesicles and autophagosomes, while Atg21 is only essential for Cvt vesicle formation [1].
  • Mutated Atg21-(FTTGT) is inactive during the Cvt pathway but showed only partly reduced binding to PtdIns-phosphates, suggesting further lipid binding domains in Atg21 [1].
 

Biological context of WIPI2

  • The relevance of the phosphatidylinositolphosphat-binding motif FRRGT of Atg18 and Atg21 for the Cvt pathway and autophagy [1].

References

  1. The relevance of the phosphatidylinositolphosphat-binding motif FRRGT of Atg18 and Atg21 for the Cvt pathway and autophagy. Krick, R., Tolstrup, J., Appelles, A., Henke, S., Thumm, M. FEBS Lett. (2006) [Pubmed]
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