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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

GMEB2  -  glucocorticoid modulatory element binding...

Homo sapiens

Synonyms: DNA-binding protein p79PIF, GMEB-2, Glucocorticoid modulatory element-binding protein 2, KIAA1269, P79PIF, ...
 
 
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High impact information on GMEB2

  • Here we present the 1.55 A resolution crystal structure of a central portion of GMEB1, encompassing its SAND domain, which shares 80% sequence identity with the GMEB2 SAND domain [1].
  • These studies shed light on the mechanism of action of GMEB-2 and further support our previous conclusion that the ability of factors to modulate the position of the dose-response curve, and the partial agonist activity, of GR complexes is unrelated to effects on the total levels of GR-induced gene expression [2].
  • Structure/activity relationships for GMEB-2: the second member of the glucocorticoid modulatory element-binding complex [2].
  • Finally, as the domain organization of GMEB-2 and -1 is extremely similar, we conclude that the quantitative differences in activities derive from variations in amino acid sequence rather than more global features of protein structure [2].
 

Associations of GMEB2 with chemical compounds

  • The glucocorticoid-modulatory element-binding proteins, GMEB1 and GMEB2, are ubiquitous, multifunctional DNA-binding proteins with important roles in the modulation of transcription upon steroid hormone activation [1].

References

  1. Crystal structure and nuclear magnetic resonance analyses of the SAND domain from glucocorticoid modulatory element binding protein-1 reveals deoxyribonucleic acid and zinc binding regions. Surdo, P.L., Bottomley, M.J., Sattler, M., Scheffzek, K. Mol. Endocrinol. (2003) [Pubmed]
  2. Structure/activity relationships for GMEB-2: the second member of the glucocorticoid modulatory element-binding complex. Chen, J., He, Y., Simons, S.S. Biochemistry (2004) [Pubmed]
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