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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Ogt  -  O-linked N-acetylglucosamine (GlcNAc)...

Rattus norvegicus

Synonyms: O-GlcNAc transferase subunit p110, O-linked N-acetylglucosamine transferase 110 kDa subunit, OGT, UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
 
 
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Disease relevance of Ogt

  • Escherichia coli strains that are deficient in the Ada and Ogt DNA repair methyltransferases display an elevated spontaneous G:C-to-A:T transition mutation rate, and this increase has been attributed to mutagenic O(6)-alkylguanine lesions being formed via the alkylation of DNA by endogenous metabolites [1].
 

High impact information on Ogt

  • We demonstrate that, in close parallel with mutagenesis, the Ogt ATase sensitizes the bacteria to the lethal effects of these carcinogens, suggesting that one or more of the potentially mutagenic lesions induced by DBE and DBM in the presence of Ogt has additional lethal capacity [2].

References

  1. Influence of S-adenosylmethionine pool size on spontaneous mutation, dam methylation, and cell growth of Escherichia coli. Posnick, L.M., Samson, L.D. J. Bacteriol. (1999) [Pubmed]
  2. Bacterial and mammalian DNA alkyltransferases sensitize Escherichia coli to the lethal and mutagenic effects of dibromoalkanes. Abril, N., Luque-Romero, F.L., Prieto-Alamo, M.J., Rafferty, J.A., Margison, G.P., Pueyo, C. Carcinogenesis (1997) [Pubmed]
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