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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Aldh1a7  -  aldehyde dehydrogenase family 1, subfamily A7

Mus musculus

Synonyms: AI987940, ALDH class 1, ALDH-E1, ALHDII, Ahd2-like, ...
 
 
 
 
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High impact information on Aldh1a7

  • Aldh1 spans about 45 kb in length, whereas Aldh-pb spans about 35 kb [1].
  • Thus our results indicate that Aldh1 can function in retinoic acid synthesis under physiological conditions, but that the closely related Aldh-pb does not share this property [1].
  • The promoter regions of Aldh1 and Aldh-pb demonstrate high sequence similarity with those of human ALDH1 and rat ALDH-PB [1].
  • During the cloning process, an additional closely related gene was also isolated and named Aldh-pb, owing to its high amino acid sequence identity (92%) with the rat phenobarbitol-inducible ALDH protein (ALDH-PB) [1].
  • Molecular analysis of two closely related mouse aldehyde dehydrogenase genes: identification of a role for Aldh1, but not Aldh-pb, in the biosynthesis of retinoic acid [1].
 

Anatomical context of Aldh1a7

  • Expression of Aldh1 and Aldh-pb is tissue-specific, with mRNAs for both genes being found in the liver, lung and testis, but not in the heart, spleen or muscle [1].

References

  1. Molecular analysis of two closely related mouse aldehyde dehydrogenase genes: identification of a role for Aldh1, but not Aldh-pb, in the biosynthesis of retinoic acid. Hsu, L.C., Chang, W.C., Hoffmann, I., Duester, G. Biochem. J. (1999) [Pubmed]
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