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Gene Review

Cdk8  -  cyclin-dependent kinase 8

Mus musculus

Synonyms: Cell division protein kinase 8, Cyclin-dependent kinase 8, Mediator complex subunit CDK8, Mediator of RNA polymerase II transcription subunit CDK8
 
 
 
 
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High impact information on Cdk8

  • Importantly, Mediator was inactive (Cdk8+) under basal conditions but was activated (Cdk8-) upon induction [1].
  • However, in PARP-1(-/-) cells, Mediator was retained in its inactive state (Cdk8+) upon induction consistent with the absence of gene expression [1].

References

  1. PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator. Pavri, R., Lewis, B., Kim, T.K., Dilworth, F.J., Erdjument-Bromage, H., Tempst, P., de Murcia, G., Evans, R., Chambon, P., Reinberg, D. Mol. Cell (2005) [Pubmed]
 
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