Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Vnn3 - vanin 3

Mus musculus

Synonyms: Vanin-3, Vascular non-inflammatory molecule 3

Min-Oo, G. et al., Kimura, T. et al.

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High impact information on Vnn3

The absence of Vnn messenger RNA expression and lack of pantetheinase protein activity in tissues are associated with susceptibility to malaria and are linked to a complex rearrangement in the Vnn3 promoter region [1].
The sequences of the other cDNA fragments were identical to those of contrapsin, transketolase, and vanin-3 [2].

Biological context of Vnn3

Vnn3/Vnn1 map within a conserved haplotype block and show expression levels that are strictly cis-regulated by this haplotype [1].

References

Complex genetic control of susceptibility to malaria: positional cloning of the Char9 locus. Min-Oo, G., Fortin, A., Pitari, G., Tam, M., Stevenson, M.M., Gros, P. J. Exp. Med. (2007) [Pubmed]
Metallothionein-null mice express altered genes during development. Kimura, T., Oguro, I., Kohroki, J., Takehara, M., Itoh, N., Nakanishi, T., Tanaka, K. Biochem. Biophys. Res. Commun. (2000) [Pubmed]

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