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Gene Review

Serpina3k  -  serine (or cysteine) peptidase inhibitor,...

Mus musculus

Synonyms: 1300001I07Rik, Contrapsin, D12Rp54, MMCM2, MMSpi2, ...
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Disease relevance of Serpina3k


High impact information on Serpina3k


Chemical compound and disease context of Serpina3k


Biological context of Serpina3k


Anatomical context of Serpina3k


Associations of Serpina3k with chemical compounds

  • Inhibitory spectrum of mouse contrapsin and alpha-1-antitrypsin against mouse serine proteases [11].
  • A glycoprotein with Mr 63,000 purified from rat serum was found to inhibit trypsin activity but not chymotrypsin or elastase activity, resembling contrapsin purified from mouse serum [12].
  • Treatment of adult worms with deoxycholate resulted in a change in the electrophoretic behaviour of worm-derived contrapsin [9].
  • After extraction of these parasites with Triton X-114, contrapsin was found in the aqueous phase of the detergent, suggesting it is unlikely to be an integral membrane protein [9].
  • Estradiol administration to intact females caused a marked elevation in contrapsin level but a decrease in alpha 1-antiprotease level [13].

Regulatory relationships of Serpina3k

  • The latter two were up-regulated, whereas contrapsin was down-regulated in neonatal MT-null mice [14].

Other interactions of Serpina3k

  • The primary structure of each of the three proteins has about 70% homology with that of mouse contrapsin, in contrast to 43-46% homology with that of rat alpha 1-protease inhibitor [12].
  • Contrapsin inactivated trypsin, but did not significantly affect chymotrypsin, pancreatic elastase, or pancreatic kallikrein [1].
  • Seventy-seven spots/spot chains from the reducing gels were identified by HPLC MS/MS, representing 28 distinct proteins, including a species-specific protease inhibitor, contrapsin, and high levels of carboxylesterase [15].
  • Five secreted proteins including three protease inhibitors (fetuin-A, alpha-1 antitrypsin 1-6, and contrapsin) were identified from tumor masses at the regressive stage [16].

Analytical, diagnostic and therapeutic context of Serpina3k


  1. Trypsin inhibitors in guinea pig plasma: isolation and characterization of contrapsin and two isoforms of alpha-1-antiproteinase and acute phase response of four major trypsin inhibitors. Suzuki, Y., Yoshida, K., Ichimiya, T., Yamamoto, T., Sinohara, H. J. Biochem. (1990) [Pubmed]
  2. Synthesis of contrapsin and alpha-1-antiproteinase in inflamed and tumor-bearing mice. Yamamoto, K., Suzuki, Y., Sinohara, H. Biochem. Int. (1988) [Pubmed]
  3. Pattern of serum protein gene expression in mouse visceral yolk sac and foetal liver. Meehan, R.R., Barlow, D.P., Hill, R.E., Hogan, B.L., Hastie, N.D. EMBO J. (1984) [Pubmed]
  4. A genetic locus closely linked to a protease inhibitor gene complex controls the level of multiple RNA transcripts. Hill, R.E., Shaw, P.H., Barth, R.K., Hastie, N.D. Mol. Cell. Biol. (1985) [Pubmed]
  5. Growth hormone induces two mRNA species of the serine protease inhibitor gene family in rat liver. Yoon, J.B., Towle, H.C., Seelig, S. J. Biol. Chem. (1987) [Pubmed]
  6. Cloning, structure and expression of cDNA for mouse contrapsin and a related protein. Ohkubo, K., Ogata, S., Misumi, Y., Takami, N., Sinohara, H., Ikehara, Y. Biochem. J. (1991) [Pubmed]
  7. Molecular cloning and sequence analysis of full-length cDNA coding for mouse contrapsin. Suzuki, Y., Yamamoto, K., Sinohara, H. J. Biochem. (1990) [Pubmed]
  8. Mouse plasma trypsin inhibitors: inhibitory spectrum of contrapsin and alpha-1-antitrypsin. Takahara, H., Sinohara, H. Thromb. Res. (1982) [Pubmed]
  9. Schistosoma mansoni host-parasite relationship: interaction of contrapsin with adult worms. Modha, J., Doenhoff, M.J. Parasitology (1994) [Pubmed]
  10. Interleukin 1 receptor antagonist localization exclusively in non-parenchymal cells of the mouse liver. Rokita, H., Kosz-Vnenchak, M., Stalińska, K., Stachura, J. Cytokine (1997) [Pubmed]
  11. Inhibitory spectrum of mouse contrapsin and alpha-1-antitrypsin against mouse serine proteases. Takahara, H., Sinohara, H. J. Biochem. (1983) [Pubmed]
  12. Molecular cloning and characterization of rat contrapsin-like protease inhibitor and related proteins. Ohkubo, K., Ogata, S., Misumi, Y., Takami, N., Ikehara, Y. J. Biochem. (1991) [Pubmed]
  13. Regulation by sex hormones of serum levels of contrapsin and alpha 1-antiprotease in the mouse. Yamamoto, K., Sinohara, H. Biochim. Biophys. Acta (1984) [Pubmed]
  14. Metallothionein-null mice express altered genes during development. Kimura, T., Oguro, I., Kohroki, J., Takehara, M., Itoh, N., Nakanishi, T., Tanaka, K. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  15. Reference maps of mouse serum acute-phase proteins: changes with LPS-induced inflammation and apolipoprotein A-I and A-II transgenes. Wait, R., Chiesa, G., Parolini, C., Miller, I., Begum, S., Brambilla, D., Galluccio, L., Ballerio, R., Eberini, I., Gianazza, E. Proteomics (2005) [Pubmed]
  16. Mass spectrometric proteomics profiles of in vivo tumor secretomes: Capillary ultrafiltration sampling of regressive tumor masses. Huang, C.M., Ananthaswamy, H.N., Barnes, S., Ma, Y., Kawai, M., Elmets, C.A. Proteomics (2006) [Pubmed]
  17. Molecular cloning and sequence analysis of cDNAs coding for guinea pig alpha 1-antiproteinases S and F and contrapsin. Suzuki, Y., Yoshida, K., Honda, E., Sinohara, H. J. Biol. Chem. (1991) [Pubmed]
  18. Conformational differences between mouse contrapsin and alpha-1-antitrypsin as studied by ultraviolet absorption and circular dichroism spectroscopy. Takahara, H., Shibata, S., Sinohara, H. Tohoku J. Exp. Med. (1984) [Pubmed]
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