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Gene Review:

NS2 - non-structural 12.9 kDa protein

Human coronavirus OC43

Labonté, P. et al., Nilges, K. et al.

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Disease relevance of NS2

Human papillomavirus type 16 E7 peptide-directed CD8+ T cells from patients with cervical cancer are cross-reactive with the coronavirus NS2 protein [1].
Sequence and expression of the ns2 protein gene of human coronavirus OC43 [2].
The amino acid sequence of the HCV-OC43 ns2 protein shows 92% identity with that of the Mebus strain of bovine coronavirus (BCV) [2].

Analytical, diagnostic and therapeutic context of NS2

As shown by immunofluorescence with a monospecific antiserum, the ns2 protein was expressed in the cytoplasm of HCV-OC43-infected HRT-18 cells [2].

References

Human papillomavirus type 16 E7 peptide-directed CD8+ T cells from patients with cervical cancer are cross-reactive with the coronavirus NS2 protein. Nilges, K., Höhn, H., Pilch, H., Neukirch, C., Freitag, K., Talbot, P.J., Maeurer, M.J. J. Virol. (2003) [Pubmed]
Sequence and expression of the ns2 protein gene of human coronavirus OC43. Labonté, P., Mounir, S., Talbot, P.J. J. Gen. Virol. (1995) [Pubmed]

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