Disease relevance of fatB

• The negative regulation of the expression of iron transport genes fatA and fatB in Vibrio anguillarum is mediated by a chromosome-encoded Fur protein and a plasmid pJM1-derived antisense RNA (RNAalpha), which is preferentially expressed under iron-rich conditions [1].

High impact information on fatB

• In addition, we present evidence that anguibactin itself enhanced transcription of the iron-transport genes fatA and fatB, independently of AngR and the trans-acting factor (TAF) product(s) [2].
• Sequence analysis indicated that the open reading frame corresponding to the fatB gene possesses domains that are characteristic of periplasmic proteins that bind the ferric siderophore [3].
• With the aim of elucidating the mechanism of ferric-anguibactin transport mediated by FatA, this work focuses on the identification of FatA amino acid residues that play a role in the transport of ferric-anguibactin, by analysing the transport kinetics of site-directed mutants [4].

Biological context of fatB

• In this work, a monospecific antiserum against an oligopeptide containing the last 27 amino acids of the carboxy-terminal region from this open reading frame was used to demonstrate that fatB encodes a 35 kDa protein that is essential for iron transport [3].

References