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Gene Review

bvgS  -  virulence sensor protein

Bordetella bronchiseptica RB50

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Disease relevance of bvgS

  • We characterized a third state, the intermediate (Bvg(i)) phase, which can be induced by introducing a 1-bp substitution into bvgS (the bvgS-I1 mutation) or by growing B. pertussis under conditions intermediate between those leading to the Bvg(+) and Bvg(-) phases [1].

High impact information on bvgS

  • Wild-type B. bronchiseptica 5376 attached very efficiently to dendritic cells, whereas the bvg mutant ATCC 10580, wild-type strain BB7865, and its spontaneous delta bvgS mutant BB7866 bound less efficiently [2].
  • Wild-type (Bvg+) strains are motile and produce peritrichous flagella only in the presence of modulating signals, whereas Bvg- (delta bvgAS or delta bvgS) strains are motile in the absence of modulators [3].


  1. Evaluation of the role of the Bvg intermediate phase in Bordetella pertussis during experimental respiratory infection. Vergara-Irigaray, N., Chávarri-Martínez, A., Rodríguez-Cuesta, J., Miller, J.F., Cotter, P.A., Martínez de Tejada, G. Infect. Immun. (2005) [Pubmed]
  2. Invasion and intracellular survival of Bordetella bronchiseptica in mouse dendritic cells. Guzman, C.A., Rohde, M., Bock, M., Timmis, K.N. Infect. Immun. (1994) [Pubmed]
  3. The bvgAS locus negatively controls motility and synthesis of flagella in Bordetella bronchiseptica. Akerley, B.J., Monack, D.M., Falkow, S., Miller, J.F. J. Bacteriol. (1992) [Pubmed]
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