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Gene Review

vir-18  -  vir-repressed protein

Bordetella pertussis Tohama I

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Disease relevance of vir-18


High impact information on vir-18

  • We used sodium dodecyl sulfate-polyacrylamide gel electrophoresis and isoelectric focusing techniques to demonstrate the existence of at least 22 vir-repressed molecules which are increased in the avirulent phenotype [3].
  • Expression of this class, the bvg-repressed genes (vrgs [for vir-repressed genes]), is reduced under conditions in which expression of the aforementioned bvg-activated virulence factors is maximal; this repression is dependent upon the presence of an intact bvgAS locus [4].


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