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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

cyaB  -  cyclolysin secretion/procession ATP...

Bordetella pertussis Tohama I

 
 
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High impact information on cyaB

  • The cyaA gene encodes a virulence factor, cyclolysin, a bifunctional protein exhibiting both adenylate cyclase and haemolytic activities while the cyaB, D and E gene products are necessary for cyclolysin transport [1].
  • The gene products of cyaB and cyaD are highly similar to HlyB and HlyD, known to be necessary for the transport of HlyA across the cell envelope and for its release into the external medium [2].
  • Complementation and functional studies indicate that the B.pertussis adenylate cyclase-haemolysin bifunctional protein is secreted by a mechanism similar to that described for E.coli alpha-haemolysin, requiring, in addition to the cyaB and cyaD gene products, the presence of a third gene product specified by the cyaE gene [2].
  • The cyaB, D and E gene products are necessary for CyaA transport, and the cyaC gene product is required to activate CyaA [3].

References

  1. Virulence dependent and independent regulation of the Bordetella pertussis cya operon. Laoide, B.M., Ullmann, A. EMBO J. (1990) [Pubmed]
  2. Secretion of cyclolysin, the calmodulin-sensitive adenylate cyclase-haemolysin bifunctional protein of Bordetella pertussis. Glaser, P., Sakamoto, H., Bellalou, J., Ullmann, A., Danchin, A. EMBO J. (1988) [Pubmed]
  3. High-level synthesis of active adenylate cyclase toxin of Bordetella pertussis in a reconstructed Escherichia coli system. Sebo, P., Glaser, P., Sakamoto, H., Ullmann, A. Gene (1991) [Pubmed]
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